Jin-Dong YANG

Associate Professor

S905, Meng Min Wai Science and Technology Bldg,

Tel: 86-10-62787136

Email: jdyang@mail.tsinghua.edu.cn

Dr. Jin-Dong Yang was graduated from Nankai University (2009). He obtained his Ph.D. degree from Nankai University (2014), followed by the post-doctorial research work at the same campus (2014-2017). He has joined Tsinghua University since 2017 and was promoted as an associate professor in 2021. He is interested in bond energetics as well as applications of bond energies in orgainc syntheses and mechainsm studies.

Selected publications:

1. Yang, J.-D.; Cheng, J.-P.*; et al. Internet Bond-energy Databank (pKa and BDE)-iBonD: http://ibond.nankai.edu.cn.

2. Xue, J.; Zhang, Y.-S.; Huan, Z.; Luo, H.-T.; Dong, L.; Yang, J.-D.*; Cheng, J.-P., Phosphonium-Catalyzed Monoreduction of Bisphosphine Dioxides: Origin of Selectivity and Synthetic Applications. J. Am. Chem. Soc. 2024, 146, 9335-9346.

3. Xue, J.; Zhang, Y.-S.; Huan, Z.; Yang, J.-D.*; Cheng, J.-P., Deoxygenation of Phosphine Oxides by PIII/PV=O Redox Catalysis via Successive Isodesmic Reactions. J. Am. Chem. Soc. 2023, 145, 15589–15599.

4. Zhang, W.; Luo, H.-T.; Yang, J.-D.*, Breakthrough in phosphonylation of alkyl radicals: Alternative access of alkyl phosphonates. Chem 2023, 9, 2735-2737.

5. Wu, J.-Y.; Mo, B.-R.; Yang, J.-D.*; Cheng, J.-P.*, A Distinctive Pattern for Substituent Effects on Transition Metal Centers: Enhanced Electron-Donating Capacity of Cationic Palladium Species. CCS Chem. 2022, 5, 1163-1175.

6. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.*, Chemoselective catalytic hydrodefluorination of trifluoromethylalkenes towards mono-/gem-di-fluoroalkenes under metal-free conditions. Nat. Commun. 2021, 12, 2835.

7. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.*, Recent progress in reactivity study and synthetic application of N-heterocyclic phosphorus hydrides. Natl. Sci. Rev. 2021, 8, nwaa253.

8. Wu, J.-Y.; Li, Z.; Yang, J.-D.*; Cheng, J.-P.*, Bonding Energetics of Palladium Amido/Aryloxide Complexes in DMSO: Implications for Palladium-Mediated Aniline Activation. Angew. Chem. Int. Ed. 2020, 59, 23782-23790.

9. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.*, Diazaphosphinyl radical-catalyzed deoxygenation of α-carboxy ketones: a new protocol for chemo-selective C–O bond scission via mechanism regulation. Chem. Sci. 2020, 11, 8476-8481.

10. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.*, Diazaphosphinanes as hydride, hydrogen atom, proton or electron donors under transition-metal-free conditions: thermodynamics, kinetics, and synthetic applications. Chem. Sci. 2020, 11, 3672-3679.

11. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.*, Exploiting the radical reactivity of diazaphosphinanes in hydrodehalogenations and cascade cyclizations. Chem. Sci. 2020, 11, 4786-4790.

12. Luo, W.; Mao, C.; Ji, P.; Wu, J.-Y.; Yang, J.-D.*; Cheng, J.-P.*, Counterintuitive solvation effect of ionic-liquid/DMSO solvents on acidic C–H dissociation and insight into respective solvation. Chem. Sci. 2020, 11, 3365-3370.

13. Zhang, J.; Yang, J.-D.*; Cheng, J.-P.*, A Nucleophilicity Scale for the Reactivity of Diazaphospholenium Hydrides: Structural Insights and Synthetic Applications. Angew. Chem. Int. Ed. 2019, 58, 5983-5987.

14. Yang, J.-D.*; Xue, J.; Cheng, J.-P.*, Understanding the role of thermodynamics in catalytic imine reductions. Chem. Soc. Rev. 2019, 48, 2913-2926.

15. Zhang, J.#; Yang, J.-D.#; Zheng, H.; Xue, X.-S.*; Mayr, H.*; Cheng, J.-P.*, Exploration of the Synthetic Potential of Electrophilic Trifluoromethylthiolating and Difluoromethylthiolating Reagents. Angew. Chem. Int. Ed. 2018, 57, 12690-12695.

16. Yang, J.-D.#; Ji, P.#; Xue, X.-S.; Cheng, J.-P.*, Recent Advances and Advisable Applications of Bond Energetics in Organic Chemistry. J. Am. Chem. Soc. 2018, 140, 8611-8623.