向 宇 Yu XIANG
副教授，博士生导师
电话：+86-10-62782759，邮件：xiang-yu@tsinghua.edu.cn
地址：北京市海淀区清华大学生命科学新馆142，邮编100084
教育背景
2000.9-2004.7 清华大学，化学系，学士（导师：巨勇教授）
2004.9-2009.7 清华大学，化学系，博士（导师：童爱军教授）
工作履历
2009.7-2012.11 美国伊利诺伊大学香槟分校，博士后（Prof. Yi Lu）
2012.12-现在 清华大学化学系，副教授
研究领域
核酸硫化学，可控基因编辑，蛋白互作共价抑制剂
研究概况
向宇课题组致力于核酸硫化学修饰新方法的开发，以此构建（1）基于化学修饰短链核酸的可控基因编辑系统、（2）蛋白互作共价短链核酸抑制剂的体外筛选技术，并（3）研究高等生物细胞内RNA硫代磷酸二酯的存在与潜在功能。
研究小组主页（英文）：https://xiang-lab.com
学术成果
代表性论文
1. Liu, R.#; Jiang, D. F.#; Yun, Y. F.; Feng, Z.; Zheng, F. F.*; Xiang, Y.*; Fan, H. H.; Zhang, J. J.*, Photoactivatable Engineering of CRISPR/Cas9-Inducible DNAzyme Probe for In Situ Imaging of Nuclear Zinc Ions. Angewandte Chemie-International Edition, 2024, 63, e202315536
2. Qin Z. C. #; Zhang K. N. #; He P.; Zhang X.; Xie M.; Fu Y. C.; Gu C. M.; Zhu Y. Y.; Tong A. J.; Wei H. P.; Zhang C.; Xiang Y.*, Discovering Covalent Inhibitors of Protein-Protein Interactions from Trillions of Sulfur(VI) Fluoride Exchange-Modified Oligonucleotides. Nature Chemistry, 2023, 15, 1705-1714.
3. Shang, J. C.; He, L.; Wang, J. Y.; Tong, A. J.; Xiang, Y.*, In Situ Visualizing Nascent mRNA by DNA-Templated Oxidative Amination of 4-Thiouridine. Bioconjugate Chemistry, 2022, 33, 164-171.
4. Gu C. M.; Xiao, L.; Shang, J. C.; Xu, X.; He, L.; Xiang, Y.*, Chemical Synthesis of Stimuli-Responsive Guide RNA for Conditional Control of CRISPR-Cas9 Gene Editing. Chemical Science, 2021, 12, 9934-9945.
5. Wang, J. Y.; Shang, J. C.; Qin, Z. C.; Tong, A. J.; Xiang, Y.*, Selective and Sensitive Fluorescence "Turn-On" Detection of 4-Thiouridine in Nucleic Acids via Oxidative Amination. Chemical Communications 2019, 55, 13096-13099.
6. Xiao, L.#; Gu, C. M.#; Xiang, Y.*, Orthogonal Activation of RNA-Cleaving DNAzymes in Live Cells by Reactive Oxygen Species. Angewandte Chemie-International Edition 2019, 58, 14167-14172.
7. Feng, M. L.; Gu, C. M.; Sun, Y. P.; Zhang, S. Y.; Tong, A. J.; Xiang, Y.*, Enhancing Catalytic Activity of Uranyl-Dependent DNAzyme by Flexible Linker Insertion for More Sensitive Detection of Uranyl Ion. Analytical Chemistry 2019, 91, 6608-6615.
8. Feng, M. L.; Ruan, Z. Y.; Shang, J. C.; Xiao, L.; Tong, A. J.; Xiang, Y.*, Photocaged G-Quadruplex DNAzyme and Aptamer by Post-Synthetic Modification on Phosphodiester Backbone. Bioconjugte Chemistry 2017, 28, 549-555.
9. Xiao, L.; Zhou, Z. J.; Feng, M. L.; Tong, A. J.; Xiang, Y.*, Cationic Peptide Conjugation Enhances the Activity of Peroxidase-Mimicking DNAzymes. Bioconjugate Chemistry 2016, 27, 621-627.
10. Wang, X. Y.; Feng, M. L.; Xiao, L.; Tong, A. J.; Xiang, Y.*, Postsynthetic Modification of DNA Phosphodiester Backbone for Photocaged DNAzyme. ACS Chemical Biology 2016, 11, 444-451.
