刘 磊    教授、博士生导师

Tel:010-62780027;Email:lliu@mail.tsinghua.edu.cn

 

教育背景

1995 - 1999    中国科学技术大学, 本科

1999 - 2004    Columbia University, 博士

2004 - 2007    Scripps Research Institute, 博士后

研究领域

蛋白质化学合成

学术成果

近期研究: 

1、        Practical chemical synthesis of atypical ubiquitin chains by using an isopeptide linked Ub isomer. Angew. Chem. Int. Ed. 201756, 13333.

2、        Chemical synthesis of membrane proteins by the removable backbone modification method. Nature Protocols 2017, 12, 2554.

3、        Removable backbone modification method for the chemical synthesis of membrane proteins. Acc. Chem. Res. 2017, 50, 1143.

4、        A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation. Nature Commun. 2017, 8, 14846.

5、        Monomer/oligomer quasi-racemic protein crystallography. J. Am. Chem. Soc. 2016, 138, 14497. 

6、        Quasi-racemic X-ray structures of K27-linked ubiquitin chains prepared by total chemical synthesis. J. Am. Chem. Soc. 2016, 138, 7429. 

7、        A synthetic molecular system capable of mirror-image genetic replication and transcription. Nature Chem. 2016, 8, 698. 

8、        Robust chemical synthesis of membrane proteins through a general method of removable backbone modification. J. Am. Chem. Soc. 2016, 138, 3553. 

9、        Utilization of a photoactivatable antigen system to examine B cell probing termination and the B cell receptor sorting mechanisms during B cell activation. Proc. Natl. Acad. Sci. USA 2016, 113, E558.