Prof. Yanmei LI , Ph.D

Department of Chemistry, Tsinghua University, Beijing 100084, P.R.China

Tel: 008610-62772259

Fax: 008610-62781695

e-mail: liym@mail.tsinghua.edu.cn

  

EDUCATION:

1982.9-1987.7 Department of Chemistry, TsinghuaUniversity

Bachelor of Science (Honours in Chemistry)

1987.9-1989.12 Department of Chemistry, TsinghuaUniversity

Master of Science

1989.12-1992.7 Department of Chemistry, TsinghuaUniversity

Doctor of Philosophy

 

EXPERIENCE AND POSITIONS:

1992.7-1993.12 Department of Chemistry, TsinghuaUniversity Lecturer

1993.12-1998.8 Department of Chemistry, TsinghuaUniversity Associate Professor

1996.10-1997.10 Institute of Organic Chemistry, University of Karlsruhe, Germany Postdoctor

1998.8-present Department of Chemistry, TsinghuaUniversity Professor 

 

FIELDS OF INTEREST:

 

1. Bioorganic Chemistry

    Peptide synthesis and their structures

    Synthesis of Bio-conjugates

2. Biotransformation and its application on the organic synthesis

    Biotransformation reactions

    Synthesis of enzymatic protecting groups

3. Biomembrane

    Fluidity of membrane phospholipid

    Secondary structure of membrane proteins

    LB membrane

4. Bio-organophosphorus Chemistry

    Phosphorus in life process

    Synthesis and reactivity study on phosphorus compounds

Selected Publications:

1. Du JT, Li YM*, Wei W, Wu GS, Zhao YF, Kanazawa K, Nemoto T, Nakanishi H, Low Barrier Hydrogen Bond Between Phosphate and Amide Group in Phosphopeptide, Journal of the American Chemical Society, 2005,127, 16350-16351

2. Chen YX, Du JT, Zhou LX, Liu XH, Zhao YF, Nakanishi H & Li YM*, Alternative O-GlcNAcylation and O-phosphorylation of Ser16 Inducing Different Conformational Disturbance to the N-terminal Peptides of Murine Estrogen Receptor β, Chemistry & Biology, 2006,13, 937-944

3. Wu WH, Lei P, Liu Q, Hu J, Gunn A, Chen MS, Rui YF, Su XY, Xie ZP, Zhao YF, Bush AI*, Li YM*, Sequestration of copper from β-amyloid promotes selective lysis by cyclen-hybrid cleavage agents, Journal of Biological Chemistry, 2008, 283(46), 31657-31664

4. Yu YP, Lei P, Hu J, Wu WH, Zhao YF & Li YM*, Copper-induced cytotoxicity: reactive oxygen species or islet amyloid polypeptide oligomer formation, Chemical Communication, 2010, 46, 6909-6911