Prof. Hua FU , Ph. D.

Contact address:

Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China

Tel.:86-10-62797186

Fax:86-10-62781695

Email:fuhua@mail.tsinghua.edu.cn

 

Education and Training:

BSc: Wuhan University (1989)

PhD: Department of Chemistryat TsinghuaUniversity(1998)

Postdoc: Department of Chemistryat the Ohio StateUniversity(2000-2002)

 

 

Research Field:

Organic Synthetic Chemistry

Bioorganic Chemistry

 

Research Interests:

Catalytic Organic Synthesis

Design, Synthesis and Biological Activity of Enzyme Inhibitors

 

Selected Publications: 

Liu XW, Fu H*, Jiang YY, Zhao YF, A Simple and Highly Efficient Approach to Quinazolinones under Mild Copper-Catalyzed Conditions, Angewandte Chemie International Edition, 2009, 48(2), 348-351.

Yang DS, Fu H*, A Simple and Practical Copper-Catalyzed Approach to Substituted Phenols from Aryl Halides by Using Water as the Solvent, Chemistry-A European Journal, 2010,16(8), 2366-2370.

Lu JY, Gong XY, Yang HJ, Fu H*, Concise copper-catalyzed one-pot tandem synthesis of benzimidazo[1,2-b]isoquinolin-11-one derivatives, Chemical Communications, 2010, 46(23), 6333-6335.

Gong XY, Yang HJ, Liu HX, Jiang YY, Zhao YF, Fu H*, Simple and Efficient Copper-Catalyzed Approach to 2,4-Disubstituted Imidazolones, Organic Letters, 2010 12(14): 3128-3131.

Wang F, Liu HX, Fu H*, Jiang YY, Zhao YF, An Efficient One-Pot Copper-Catalyzed Approach to Isoquinolin-1(2H)-one Derivatives, Organic Letters, 2009, 11 (11), 2469-2472,

Liu XW, Fu H*, Jiang YY, Zhao YF“A Simple and Highly Efficient Approach to Quinazolinones under Mild Copper-Catalyzed Conditions” Angew. Chem. Int. Ed. 48(2), 348-351 (2009).

Rao HH, Fu H*, Jiang YY, Zhao YF "Easy Copper-Catalyzed Synthesis of Primary Aromatic Amines by Coupling Aromatic Boronic Acids with Aqueous Ammonia at Room Temperature"Angew. Chem. Int. Ed. 48(6), 1114-1116 (2009).

Wang L, Fu H*, Jiang YY, Zhao YF “Highly Efficient Copper-Catalyzed Amidation of Aldehydes via C-H Activation” Chem. Eur. J. 14(34), 10722-10726 (2008).

Rao HH, Jin Y, Fu H*, Jiang YY, Zhao YF “A Versatile and Efficient Ligand for Formation of Copper-Catalyzed C-N, C-O and P-C Bonds: Pyrrolidine-2-Phosphonic Acid Phenyl Monoester” Chem. Eur. J. 12(13): 3636-3646 (2006).

Huang C, Fu H*, Jiang YY*, Zhao YF“Highly Efficient Copper-Catalyzed Cascade Synthesis of Quinazoline ans Quinazolinone Derivatives”Chem. Commun.(47), 6333-6335(2008).

Niu MY, Fu H*, Jiang YY, Zhao YF “Copper-Catalyzed Addition of H-Phosphine Oxides to Alkynes Forming Alkenylphosphine Oxides” Chem. Commun. (3): 272-274 (2007).

Ai HW, Fu H*, Zhao YF “Novel Synthetic Method of Phosphonamidate Peptides and Its Application in Peptide Sequencing via Multistage Mass Spectrometry” Chem. Commun. (21): 2724-2725 (2003).

Fu H*, Han B, Zhao YF “Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride” Chem. Commun. (1): 134-135 (2003).

Wang F, Liu HX, Fu H*, Jiang YY*, Zhao YF“Highly Efficient Iron(II) Chloride/N-Bromosuccinimide-Mediated Synthesis of Imides and Acylsulfonamides” Adv. Synth. Catal.351(1-2), 246 -252 (2009).

Wang F, Fu H*, Jiang YY, Zhao YF“Copper-Catalyzed Cycloaddition of Sulfonyl Azides with Alkynes to Synthesize N-Sulfonyltriazoles ‘on Water’ at Room Temperature” Adv. Synth. Catal.350(11-12), 1830-1834 (2008).

Guo X, Rao HH, Jin Y, Fu H*, Jiang YY, Zhao YF“An Inexpensive and Efficient Copper Catalyst for N-Arylation of Amines, Amides and Nitrogen-containing Heterocycles” Adv. Synth. Catal. 348(15): 2197-2202 (2006).

Wang F, Fu, H*, Jiang YY, Zhao YF“Quick and Highly Efficient Copper-Catalyzed Cycloaddition of Aliphatic and Aryl Azides with Terminal Alkynes ‘on Water’” Green Chem.10(4), 452-456 (2008).

Wang Z, Zhang YM, Fu, H*, Jiang YY, Zhao YF “Efficient Intermolecular Iron-Catalyzed Amidation of C-H Bonds in the Presence of N-Bromosuccinimide”Org. Lett.10(9): 1863-1866 (2008).

Zhang,YM, Fu, H*, Jiang, YY, Zhao YF “Copper-Catalyzed Amidation of sp3 C-H Bonds Adjacent to a Nitrogen Atom”Org. Lett.9(19): 3813-3816 (2007).

Yang T, Lin CX, Fu H*, Jiang YY, Zhao YF “Copper-Catalyzed Synthesis of Medium- and Large-Sized Nitrogen Heterocycles via N-Arylation of Phosphoramidates and Carbamates” Org. Lett.7(21): 4781-4784 (2005)

Li XS, Zhang DW,Pang H, Shen F, Fu H*,Jiang YY, Zhao YF “Synthesis of a Diverse Series of Phosphacoumarins with Biological Activity” Org. Lett.7(22): 4919-4922 (2005).

Yang D, Fu, H*, Hu L*, Jiang, YY, Zhao YF“Copper-Catalyzed Synthesis of Benzimidazoles via Cascade Reactions of o-Haloacetanilide Derivatives with Amidine Hydrochlorides”J. Org. Chem.73(19): 7841-7844 (2008).

Liu XW, Zhang YM, Wang L, Fu, H*, Jiang YY, Zhao YF “General and Efficient Copper-Catalyzed Amidation of Saturated C-H Bonds Using N-Halosuccinimides as the Oxidants”, J. Org. Chem.73(16): 6207-6212 (2008).

Niu MY, Yin ZM, Fu, H*, Jiang, YY, Zhao YF “Copper-Catalyzed Coupling of Tertiary Aliphatic Amines with Terminal Alkynes to Propargylamines via C-H Activation”, J. Org. Chem.73(10): 3813-3816 (2008).

Gao XT, Fu, H*, Qiao RZ*, Jiang, YY, Zhao YF“Copper-Catalyzed Synthesis of Primary Arylamines via Cascade Reactions of Aryl Halides with Amidine HydrochloridesJ. Org. Chem.73(17): 6864-6866 (2008).

Jiang DS, Fu H*, Jiang YY, Zhao YF “CuBr/rac-BINOL-Catalyzed N-Arylations of Aliphatic Amines at Room Temperature” J. Org. Chem. 72(2): 672-674 (2007)

Huang C, Tang X, Fu H*, Jiang YY, Zhao YF “Proline/Pipecolinic Acid-Promoted Copper-Catalyzed P-Arylation” J. Org. Chem.71(13): 5020-5022 (2006)

Zhu JG, Fu H*, Jiang YY, Zhao YF “A General and Chemoselective Synthesis of Phosphoramidates through Reaction of Silylated Nucleoside Di- and Triphosphates with Silylated Amines Containing Multifunctional Groups” J. Org. Chem.71(21): 1721-1724 (2006)

Rao HH, Fu H*, Jiang YY, Zhao YF “Copper-Catalyzed Arylation of Amines Using Diphenyl Pyrrolidine-2-phosphonate as the New Ligand” J. Org. Chem. 70(20): 8107-8109 (2005)

Zhu JG, Han B, Fu H*, Jiang YY, Zhao YF “Novel Synthesis of Nucleoside 5-Phosphoramidates through Reaction of Nucleoside Triphosphates with Amines Mediated by Trimethylsilyl Chloride” J. Org. Chem.70(17): 6676-6679 (2005).