Professor Dr. Jin-Ming Lin

Distinguished Professor of Cheung Kung Scholars,
Ministry of Education, China
Director of Institute of Analytical Chemistry,
Director of Analysis Center Tsinghua University

 

Contact: Department of Chemistry, Tsinghua University, Beijing 100084, China,

Office: Rm. 321, Hetian Builiding,

Labs:  Rms 329, 330, Hetian Building

Tel/Fax:  +86-10-62792343 (Office), +86-10-62792607 (Lab)

E-mail: jmlin@mail.tsinghua.edu.cn

Website of the research group: http://www.linlab-tsinghua-edu.org

  

Biography

Professor Jin-Ming Lin was graduated from Fuzhou University in 1984. He received a PhD degree in from Tokyo Metropolitan University in 1997. He had studied and worked in Showa University and Tokyo Metropolitan University during 1992-2002, and turn to Research Center for Eco-Environmental Science, Chinese Academy of Sciences as a research professor from 2002-2004. He is currently a full professor of Tsinghua University since 2004. He has received several awards for his contributions in chemiluminescence and separation science: Outstanding Young Chemist Award (Chinese Chemical Society, 1992), Young Analyst Award for Flow Injection Analysis (Flow Injection Section, Japan Society of Analytical Chemistry, 2000) , Kanton New Century Award (Japan Society of Analytical Chemistry, 2001), National Science Fund for Distinguished Young Scholars of China (National Natural Science Foundation of China, 2001), FIA Award for Science (Flow Injection Section, Japan Society of Analytical Chemistry, 2008), GC Contribution Award (GC Discussion Group, Japan Society of Analytical Chemistry, 2008), CAIA Awards (China Association for Instrumental Analysis, 2009 and 2010), Science and Censorship Award (General Administration of Quality Supervision, Inspection and Quarantine of the People’s Republic of China, 2009), Innovation Award (China Industry-University-Research Institute Collaboration Association, 2011), and Scientific Research Award from Beijing City Government (2013).

His research interests are microfluidic devices for cell analysis, chemiluminescence, and sample pretreatment. He is the author and co-author of 388 original research papers published in international journals, 32 reviews, 4 books and 45 patents.

(for more detail: http://www.linlab-tsinghua-edu.org/)

 

Research Area: Bio- and Environmental Analytical Chemistry
1) Microfluidic device and mass spectrometry for single cells analysis
2) Chemiluminescence/fluorescence immunoassay for protein and DAN analysis
3) Analytical Methods for negative oxygen ions and reactive oxygen species (ROS)
4) Sample pretreatment for mass spectrometry and chromatography analysis
5) Development of analytical instrumentation

 

Teaching:
1) Environmental Analytical Chemistry
2) Analytical Chemistry
3) Analytical Chemistry and Modern Society

 

Awards and Honors

1992 Outstanding Young Chemist Award (Chinese Chemical Society)
2000 Young Analyst Award for Flow Injection Analysis (Flow Injection Section, Japan Society of Analytical Chemistry)
2000 “100 Talent Program” Chinese Academy of Science
2001 Kanton New Century Award (Japan Society of Analytical Chemistry)
2001 Outstanding Young Investigator Fund, Natural Science Foundation of China
2008 FIA Award for Science (Flow Injection Section, Japan Society of Analytical Chemistry, 2008)
2008 GC Contribution Award (GC Discussion Group, Japan Society of Analytical Chemistry)
2008 Changjiang Scholars Professor, Ministry of Education, China
2009 CAIA Award (China Association for Instrumental Analysis, 2009)
2009 Science and Censorship Award (General Administration of Quality Supervision, Inspection and Quarantine of the People’s Republic of China)
2010 CAIA Award (China Association for Instrumental Analysis, 2010)
2011 Innovation Award (China Industry-University-Research Institute Collaboration Association)
2012 Meiyiqi Academic Award  (Tsinghua University, 2012)
2013 Scientific Research Award f (Beijing City Government)
2013 CAIA Award (China Association for Instrumental Analysis, 2013)
2013 Meiyiqi Academic Award  (Tsinghua University, 2013)
2013 CJK Outstanding Contribution Award (2013 China-Japan-Korea Symposium on Analytical Chemistry)
2014 Meiyiqi Academic Award  (Tsinghua University, 2014)

 

Editorial Boards
Trends in Analytical Chemistry (Elsevier), Contributing Editor (2007.01-)
Journal of Flow Injection Analysis (JAFIA, Japan), International Advisory Board (2007.01-)
International Journal of Analytical Chemistry (Hindawi), Editorial Board (2008.01-)
Talanta (Elsevier), Editorial Board (2008.01-)
Recent Patents on Nanotechnology (Hindawi), Editorial Advisory Board (2008.01-)
Current Analytical Chemistry (Bentham), Associate Editor (2009.01-)
Luminescence (Wiley), Editorial Board (2009.01-)
Toxicological & Environmental Chemistry (Taylor & Francis), Editorial Board (2011.01-)
Journal of Pharmaceutical Analysis (Xi’an Jiaoda and Elsevier), Associate Editor (2011.01-)
Chinese Chemical Letter (CCS, Elsevier), Editorial Board (2012.01-)
Science China Chemistry (Science China Press), Editorial Board(2013.01-)


Recent Publications 

Ziyi He, Qiushui Chen, Fengming Chen, Jie Zhang, Haifang Li, Jin-Ming Lin*, DNA-mediated cell surface engineering for multiplexed glycan profiling using MALDI-TOF mass spectrometry, Chemical Science, 2016, 7, 5448 – 5452.

Hui Chen, Qiang Gao, Jianzhang Li*, Jin-Ming Lin*, Graphene materials-based chemiluminescence for sensing, Journal of Photochemistry & Photobiology, C: Photochemistry Reviews, 2016, 27, 54–71.

Syed Niaz Ali Shah,Yongzan Zheng,Haifang Li,and Jin-Ming Lin*, Chemiluminescence character of ZnS quantum dots with bisulphite-hydrogen peroxidesystem in acidic medium, J. Phys. Chem. C, 2016, 120, 9308-9316.

Fengming Chen,Luyao Lin,Jie Zhang,Ziyi He, Katsumi Uchiyama,and Jin-Ming Lin*,Single cell analysis using drop-on-demand inkjet printing and probe electrospray ionization mass spectrometry, Anal. Chem., 2016, 88 (8), 4354–4360.

Jie Zhang, Fengming Chen, Ziyi He, Yuan Ma, Katsumi Uchiyama, Jin-Ming Lin*, A novel approach for precisely controlled multiple cell patterning in microfluidic chip by inkjet printing and the detection of drug metabolism and diffusion, Analyst, 2016, 141, 2940 – 2947.

Qiushui Chen, Stefanie Utech, Dong Chen, Radivoje Prodanovic, Jin-Ming Lin,* and David A. Weitz*, Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet, Lab Chip, 2016, 16, 1346-1349.

Jing Wu, Ziyi He, Qiushui Chen, Jin-Ming Lin*, Biochemical analysis on microfluidic chips, Trends in Analytical Chemistry, 2016, 80, 213–231.

Yongzan Zheng, Xiangnan Dou, Haifang Li, and Jin-Ming Lin*, Bisulfate induced chemiluminescence of g-C3N4 nanosheets and enhanced by metal ions, Nanoscale, 2016, 8, 4933 – 4937.

Wu Liu, Jin-Ming Lin*, Online monitoring of lactate efflux by multi-channel microfluidic chip-mass spectrometry for rapid drug evaluation, ACS Sensor, 2016, 1 (4), 344–347.

Xuexia Lin,Ka-Ho Leung,Ling Lin, Luyao Lin, Sheng Lin, Chung-Hang Leung,Dik-Lung Ma, Jin-Ming Lin*, Determination of cell metabolite VEGF165 and dynamic analysis of protein-DNA interactions by combination of microfluidic technique and luminescent switch-on probe, Biosensors and Bioelectronics, 2016, 79, 41-47.

Qichen Zhuang, Shiqi Wang, Jie Zhang, Ziyi He, Haifang Li, Yuan Ma *, Jin-Ming Lin*, Nephrocyte-neurocyte interaction and cellular metabolic analysis on membrane-integrated microfluidic device, Science China Chemistry, 2016, 59(2), 243-254.

Mingsha Jie, Hai-Fang Li*, Luyao Lin, Jie Zhang, Jin-Ming Lin*, Integrated microfluidic system for cell co-culture and simulation of drug metabolism, RSC Adv., 2016, 6, 54564-54572.

uyao Lin, Mingsha Jie, Fengming Chen, Jie Zhang, Ziyi He, Jin-Ming Lin*, Efficient cell capturein agarose-PDMS hybrid chip for shaped 2d culture under temozolomide stimulation, RSC Advances, 2016, 6, 75215 – 75222.

Qiushui Chen, Ziyi He, Wu Liu, Xuexia Lin, Jing Wu, Haifang Li, Jin-Ming Lin*, Engineering cell-compatible paper chips for cell culturing, drug screening and mass spectrometric sensing, Advanced Healthcare Materials, 2015, 4(15), 2291-2296.

Xuexia Lin, Qiushui Chen, Wu Liu, Jie Zhang, Shiqi Wang, Zhixiong Lin, and Jin-Ming Lin*, Oxygen-induced cell migration and on-line monitoring biomarkers modulation of cervical cancers on a microfluidic system, Sci. Rep., 2015, 5, 9643 (7 Pages).

Hui Chen,Ling Lin,Haifang Li, and Jin-Ming Lin*, Aggregation-induced structure transition of protein-stabilized zinc/copper nanoclusters for amplified chemiluminescence, ACS Nano, 2015, 9 (2), 2173–2183.

Xuexia Lin, Qiushui Chen, Wu Liu, Linglu Yi, Haifang Li, Zhihua Wang*, and Jin-Ming Lin*, Assay of multiplex proteins from cell metabolism based on tunable aptamer and microchip electrophoresis, Biosensors and Bioelectronics, 2015, 63, 105-111.

Jie Zhang, Jing Wu, Haifang Li, Qiushui Chen, Jin-Ming Lin*, An in vitro liver model on microfluidic device for analysis of capecitabine metabolite using mass spectrometer as detector,Biosensors and Bioelectronics, 2015, 68, 322–328

Zhen Lin, Xiangnan Dou, Haifang Li, Yuan Ma, Jin-Ming Lin*, Nitrite sensing based on the carbon dots-enhanced chemiluminescence from peroxynitrous acid and carbonate, Talanta, 2015, 132, 457–462.

Wu Liu, Qiushui Chen, Xuexia Lin, Jin-Ming Lin*, Online multi-channel microfluidic chip-mass spectrometry and its application for quantifying noncovalent protein-protein interactions, Analyst, 2015, 140, 1551-1554.

Hui Chen, Ling Lin, Haifang Li, and Jin-Ming Lin*, Quantum dots-enhanced chemiluminescence: mechanism and application (Invited review), Coordination Chemistry Reviews, 2014, 263/264, 86–100.

Xiangwei He, Qiushui Chen, Yandong Zhang, and Jin-Ming Lin*, Recent advances of microchip-mass spectrometry in biological analysis, Trends Anal. Chem., 2014, 53, 84-97.

Yandong Zhang, Haifang Li, Yuan Ma, and Jin-Ming Lin*, Paper spray mass spectrometry based method for analysis of droplets in a gravity-driven microfluidic chip, Analyst, 2014, 139 (5), 1023 – 1029.

Xuexia Lin, Qiushui Chen, Wu Liu, Haifang Li, and Jin-Ming Lin*, A portable microchip for ultrasensitive and high-throughput assay of thrombin by rolling circle amplification and Hemin/G-quadruplex system, Biosensors and Bioelectronics, 2014, 56, 71–76.

Niejun Wang, Sifeng Mao, Wu Liu, Jing Wu, Haifang Li*, and Jin-Ming Lin*, Online monodisperse droplets based liquid-liquid extraction on a continuously flowing system by using microfluidic devices, RSC Adv., 2014, 4(23),11919-11926.

Linglu Yi,Xueqin Xu*, Xuexia Lin,Haifang Li, Yuan Ma, Jin-Ming Lin*, High-throughput and automatic typing via human papillomavirus identification map for cervical cancer screening and prognosis, Analyst, 2014, 139 (13), 3330 – 3335.

Jing Wu,Haifang Li*,Qiushui Chen,Xuexia Lin,Wu Liu,and Jin-Ming Lin*, Statistic single-cell analysis of cell cycle-dependent quantum dot cytotoxicity and cellular uptake using microfluidic system, RSC Adv., 2014, 4 (47), 24929 – 24934.

Ruizhi Ning, Shiqi Wang, Jing Wu, Feng Wang*, and Jin-Ming Lin*, ZnO nanowire arrays exhibit cytotoxic distinction to cancer cells with different surface charge density: cytotoxicity is charge-dependent, Small, 2014, 10(20), 4113-4117.

Wu Liu, Niejun Wang, Xuexia Lin, Yuan Ma and Jin-Ming Lin*, Interfacing micro-sampling droplets and mass spectrometry by paper spray ionization for online chemical monitoring of cell culture, Anal. Chem., 2014, 86 (14), 7128–7134.

Bo-Tao Zhang, Hai-Fang Li, Xiaoxia Zheng, Yanguo Teng, Yan Liu*, Jin-Ming Lin*, Preparation of durable graphene-bonded titanium fibers for efficient microextraction of phthalates from aqueous matrices and analysis with gas chromatography-mass spectrometry, J. Chromatogr. A, 2014, 1370, 9-16.

Sifeng Mao, Jie Zhang, Haifang Li, Jin-Ming Lin*, A Novel Strategy for High throughput signaling molecule detection to study cell–to–cell communication, Anal. Chem., 2013, 85 (2), 868–876.

Fengming Chen, Sifeng Mao, Hulie Zeng, Shuhua Xue, Jianmin Yang, Hizuru Nakajima, Jin-Ming Lin*, Katsumi Uchiyama*, Inkjet nano-injection for high-thoughput chemiluminescence immunoassay on multicapillary glass plate, Anal. Chem., 2013, 85 (15),7413–7418.

Dan Gao, Hongxia Liu, Jin -Ming Lin*, Yini Wang, Yuyang Jiang*, Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device, Lab Chip, 2013, 13, 978-985.

Chen Luo, Yuan Ma,*, Haifang Li, Fengming Chen, Katsumi Uchiyama, Jin-Ming Lin*, Generation of pico-liter droplets of liquid for electrospray ionization with piezoelectric inkjet, J. Mass Spectrom., 2013, 48, 321-328.

Fengming Chen, Yandong Zhang, Yuri Nakagawa, Hulie Zeng, Chen Luo, Hizuru Nakajima, Katsumi Uchiyama*, Jin-Ming Lin*, A piezoelectric drop-on-demand generator for accurate sampling in capillary electrophoresis, Talanta, 2013, 107, 111-117.

Qunyan Xiao, Huiling Gao, Qipeng Yuan, Chao Lu*, Jin-Ming Lin, High-performance liquid chromatography assay of cysteine and homocysteine using fluorosurfactant-functionalized gold nanoparticles as postcolumn resonance light scattering reagents, J. Chromatogr. A, 2013, 1274, 145-150.

Dan Gao, Haifang Li*, Niejun Wang, Jin-Ming Lin*, Evaluation of the absorption of methotrexate on cells and its cytotoxicity assay by using an integrated microfluidic device coupled to mass spectrometer, Anal. Chem., 2012, 84(21), 9230-9237.

Hui Chen, Haifang Li, Jin-Ming Lin*, Determination of ammonia in water based on chemiluminescence resonance energy transfer between peroxymonocarbonate and branched NaYF4:Yb3+/Er3+ nanoparticle, Anal. Chem., 2012, 84, 8871-8879.

Xiangnan Dou, Zhen Lin, Hui Chen, Yongzan Zheng, Chao Lu, and Jin-Ming Lin*, Production of superoxide anion radicals as an evidence for carbon nanodots as electron donors by chemiluminescence method, Chem. Commun., 2013, 49(52), 5871– 5873.

Qiushui Chen, Jing Wu, Qichen Zhuang, Xuexia Lin, Jie Zhang, and Jin-Ming Lin*, Microfluidic isolation of highly pure embryonic stem cells using feeder-separated co-culture system, Sci. Rep., 2013, 3, 2433(6 pages)

Qiushui Chen,  Jing Wu,  Yan-Dong Zhang,  Zhen Lin, Jin-Ming Lin*, Targeted isolation and analysis of single tumor cells with aptamer-encoded microwell array on microfluidic device, Lab Chip, 2012, 12(24), 5180-5185.

Jing Wu, Qiushui Chen, Wu Liu, Yandong Zhang, Jin-Ming Lin*, Cytotoxicity of quantum dots assay on a microfluidic 3D-culture device based on modeling diffusion process between blood vessels and tissues, Lab Chip, 2012, 12, 3474-3480.

Hui Chen, Ruibo Li, Haifang Li, Jin-Ming Lin, Plasmon-assisted enhancement of the ultraweak chemiluminescence using Cu/Ni metal nanoparticles, J. Phys. Chem. C, 2012, 116, 14796-14803.

Fengming Chen, Zhen Lin, Yongzan Zheng, Hulie Zeng, Hizuru Nakajima, Katsumi Uchiyama, Jin-Ming Lin, Development of an automatic multi-channel ink-jet ejection chemiluminescence system and its application to the determination of horseradish peroxidase, Anal. Chim. Acta, 2012, 739, 77-82.

Ruibo Li, Takayuki Kameda, Akira Toriba, Kazuichi Hayakawa, Jin-Ming Lin, Determination of benzo[a]pyrene-7, 10-quinone in airborne particulates by using a chemiluminescence reaction of hydrogen peroxide and hydrosulfite, Anal. Chem., 2012, 84(7), 3215-3221.

Ruibo Li, Hui Chen, Ying Li,Chao Lu, Jin-Ming Lin, Enhancing effect of alcoholic solvent on hydrosulfite-hydrogen peroxide chemiluminescence system, J. Phys. Chem. A, 2012, 116(9), 2192-2197.

Qiushui Chen, Jing Wu, Yandong Zhang, Jin-Ming Lin*, Qualitative and quantitative analysis of tumor cell metabolism via stable isotope labeling assisted microfluidic chip-electrospray ionization-mass spectrometry, Anal. Chem., 2012, 84(3), 1695-1701.

Zhen Lin, Wei Xue, Hui Chen, Jin-Ming Lin, Classical oxidant induced chemiluminescence of fluorescent carbon dots, Chem. Commun., 2012, 48 (7), 1051 – 1053.

Sifeng Mao, Dan Gao, Wu Liu, Huibin Wei, Jin-Ming Lin, Imitation of drug metabolism in human liver and cytotoxicity assay using a microfluidic device coupled to mass spectrometric detection, Lab Chip, 2012, 12(1), 219-226.