Prof. Huaping XU

Tel: 86-10-62773672

E-mail: xuhuaping@tsinghua.edu.cn

Group page: http://xuslab.com 

Prof. Dr. Huaping Xu, born in 1978, received his Bachelor degree in 2001 and Ph. D. degree in 2006 in Jilin University, China, under the supervision of Prof. Xi Zhang. During 2004-2005, he worked as an exchange student in University of Leuven, Belgium. In 2006, he joined Prof. David N. Reinhoudt and Prof. Jurriaan Huskens’s group at University of Twente, the Netherlands as a post-doc. Since July 2008, he has worked at Department of Chemistry, Tsinghua University, China. He was promoted to associate professor in 2009 and full professor in 2014. In 2011, he received Young Chemists Award of Chinese Chemical Society. In 2014, he received National Natural Science fund for Distinguished Young Scholars. In 2015, he was enrolled in Outstanding Young Talents of National High-level personnel of special support program (“people plan”). In 2016, he was enrolled in Innovative Talents Cultivate Program (Youth Science and Technology Innovation Leader) from Ministry of Science and Technology. In 2017, he was enrolled in Leading Talent of National High-level personnel of special support program ("people plan"). Since 2017, he started serving as associate editor for ACS Biomaterials Science & Engineering. His current research is focused on selenium-containing polymers.

 

 

Selected Publications

1. Li, F.; Li, Y.; Yang, X.; Han, X.; Jiao, Y.; Wei, T.; Yang, D.; Xu, H.*; Nie, G.*: Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism. Angew. Chem. Int. Ed.,2018, 57, 2377. (VIP paper)

2. Li, T.; Xiang, W.; Li, F.; Xu, H.*: Self-assembly Regulated Anticancer Activity of Platinum Coordinated Selenomethionine. Biomaterials, 2018, 157, 17.

3. Ji, S.; Fan, F.; Sun, C.; Yu, Y.; Xu, H.*: Visible Light Induced Plasticity of Shape Memory Polymers. ACS Appl. Mater. Interfaces, 2017, 9, 33169.

4. Li, F.; Li, T.; Han, X.; Zhuang, H.; Nie, G.; Xu, H.*: Nanomedicine Assembled by Coordinated Selenium-Platinum Complexes Can Selectively Induce Cytotoxicity in Cancer Cells by Targeting the Glutathione Antioxidant Defense System. ACS Biomaterials Science & Engineering, 2017, DOI: 10.1021/acsbiomaterials.7b00362. (Biomaterials Science and Engineering in China Special Issue)

5. Wang, L.; Wang, W.; Cao, W.; Xu, H.*: Multi-hierarchical Responsive Polymers: Stepwise Oxidation of a Selenium- and Tellurium-Containing Block Copolymer with Sensitivity to both Chemical and Electrochemical Stimuli. Polym. Chem., 2017, 8, 4520.

6. Li, F.; Li, T.; Sun, C.; Xia, J.; Jiao, Y.; Xu, H.*: Selenium-Doped Carbon Quantum Dots (Se-CQDs) for Free Radical Scavenging. Angew. Chem. Int. Ed., 2017, 56, 9910.

7. Xia, J.; Li, F.; Ji, S.; Xu, H.*: Selenium-functionalized Graphene Oxide that Can Modulate the Balance of Reactive Oxygen Species. ACS Appl. Mater. Interfaces, 2017, 9, 21413.

8. Li, F.; Li, T.; Sun, C.; Xia, J.; Xu, H.*: Near-Infrared Light Stimuli-responsive Synergistic Therapy Nanoplatforms Based on the Coordination of Tellurium-containing Block Polymer and Cisplatin for Cancer Treatment. Biomaterials, 2017, 133, 208.

9. Ji, S.; El Mard, H.; Smet, M.; Dehaen, W.; Xu, H.*: Selenium Containing Macrocycles: Transformation between Se-N/Se-S/SeSe Bonds. Sci. China Chem., 2017, 60, 1191.

10. Zhou, W.; Li, H.; Xia, B.; Ji, W.; Ji, S.; Zhang, W.; Huang, W.*; Huo, F.*; Xu, H.*: Selenium-functionalized Metal-Organic Frameworks for Enzyme Mimics. Nano Research, 2017, DOI: 10.1007/s12274-017-1623-2.

11. Sun, C.; Ji, S.; Li, F.*; Xu, H.*: Diselenide-Containing Hyperbranched Polymer with Light-Induced Cytotoxicity. ACS Appl. Mater. Interfaces, 2017, 9, 12924.

12. Zhou, W.; Wang, L.; Li, F.; Zhang, W.; Huang, W.*; Huo, F.*; Xu, H.*: Selenium-containing Polymer@metal-organic Frameworks Nanocomposites as an Efficient Multi-responsive Drug Delivery System. Adv. Funct. Mater., 2017, 27, 1605465.

13. Xia, J.; Ji, S.; Xu, H.*: Diselenide Covalent Chemistry at the Interface: Stabilizing Asymmetric Diselenide-containing Polymer via Micelle Formation, Polym. Chem., 2016, 7, 6708.

14. Cao, W.; Li, F.; Chen, R.; Xu, H.*: Tellurium-containing Nanoparticles for Controlled Delivery of Cisplatin Based on Coordination Interaction, RSC Adv., 2016, 6, 94033.

15. Li, T.; Li, F.; Xiang, W.; Yi, Y.; Chen, Y.; Cheng, L.; Liu, Z.*; Xu., H.*: Selenium-containing Amphiphiles Reduced and Stabilized Gold Nanoparticles: Kill Cancer Cells via Reactive Oxygen Species, ACS Appl. Mater. Interfaces, 2016, 8, 22106.

16. Fan, F.; Wang, L.; Li, F.; Fu, Y.*; Xu, H.*: Stimuli-Responsive Layer-by-Layer Tellurium-Containing Polymer Films for the Combination of Chemotherapy and Photodynamic Therapy. ACS Appl. Mater. Interfaces, 2016, 8, 17004.

17. Wang, L.; Cao, W.; Xu, H.*: Tellurium-Containing Polymers: Towards Biomaterials and Optoelectronic Materials. ChemNanoMat, 2016, 2, 479.

18. Ji, S.; Xia, J.; Xu, H.*: Dynamic Chemistry of Selenium: Se–N and Se–Se Dynamic Covalent Bonds in Polymeric Systems. ACS Macro Lett., 2016, 5, 78.

19. Li, T.; Smet, M.; Dehaen, W. and Xu, H.*: Selenium–Platinum Coordination Dendrimers with Controlled Anti-Cancer Activity. ACS Appl. Mater. Interfaces, 2016, 8, 3609. (“Applied Materials and Interfaces in China” Special Issue)

20. Cao, W.; Wang, L.; Xu, H.*: Selenium/tellurium Containing Polymer Materials in Nanobiotechnology. Nano Today, 2015, 10, 717.

21. Ji, S.; Cao, W.; Yu, Y. and Xu, H.*: Visible-Light-Induced Self-Healing Diselenide-Containing Polyurethane Elastomer. Adv. Mater., 2015, 27, 7740.

22. Wang L.; Fan F.; Cao W. and Xu H.*: Ultra-sensitive ROS-responsive Coassemblies of Tellurium-Containing Molecules and Phospholipids, ACS Appl. Mater. Interfaces, 2015, 7, 16054.

23. Cao, W.; Gu, Y.; Li, T.; Xu, H.*: Ultra-sensitive ROS-responsive Tellurium-containing Polymers. Chem. Commun., 2015, 51, 7069.

24. Fang, R.; Xu, H.*; Cao, W.; Yang, L.; Zhang, X.*: Reactive Oxygen Species (ROS)-responsive Tellurium-containing Hyperbranched Polymer. Polym. Chem., 2015, 6, 2817.

25. Cao, W.; Wang, L.; Xu, H.*: Coordination Responsive Tellurium-containing Multilayer Film for Controlled Delivery. Chem. Commun., 2015, 51, 5520.

26. Huang, X.; Fang, R.; Wang, D.; Wang, J.; Xu, H.*; Wang, Y.*; Zhang, X.: Tuning Polymeric Amphiphilicity via Se-N Interactions: towards One-step Double Emulsion for Highly Selective Enzyme Mimics. Small, 2015, 11, 1537.

27. Li, T.; Yi, Y.; Xu, H.*: Selenium-containing Coordinating Assemblies with Selective Anti-cancer Activity: the Control of Reactive Oxygen Species. Acta Chim. Sinica, 2014, 72, 1209.

28. Wang, L.; Cao, W.; Yi, Y.; Xu, H.*: Dual Redox Responsive Co-assemblies of Diselenide-containing Block Copolymers and Polymer Lipids. Langmuir, 2014, 30, 5628.

29. Ji, S.; Cao, W.; Yu, Y.; Xu, H.*: Dynamic Diselenide Bonds: Exchange Reaction Induced by Visible Light without Catalysis. Angew. Chem. Int. Ed., 2014, 53, 6781. Hot Paper

30. Zeng, L.; Li, Y.; Li, T.; Cao, W.; Yi, Y.; Geng, W.; Sun, Z.*; Xu, H.*: Selenium-platinum Coordination Compounds as Novel Anticancer Drugs: Selectively Killing Cancer Cells via a ROS-mediated Apoptosis Route. Chem. Asian. J., 2014, 9, 2295.

31. Cao, W.; Gu, Y.; Meineck, M.; Li, T.; Xu, H.*: Tellurium-containing Polymer Micelles: Competitive-Ligand-Regulated Coordination Responsive Systems. J. Am. Chem. Soc., 2014, 136, 5132.

32. Cao, W.; Gu, Y.; Meineck, M.; Xu, H.*: The Combination of Chemotherapy and Radiotherapy towards More Efficient Drug Delivery. Chem. Asian. J., 2014, 9, 48 (Invited Focus Review).

33. Ji, S.; Cao, W.; Xu, H.*: A ROS Eliminating Nanocomposite Film Fabricated from Diselenide-Containing Polymer Micelles. Part. Part. Syst. Charact., 2013, 30, 1034.

34. Miao, X.; Cao, W.; Zeng, W.; Wang, J.; Gao, J.; Yang, C.; Kong, D.*; Xu, H.*; Wang, L.; Yang, Z.*: Switchable Catalytic Activity: Selenium-containing Peptides with Redox Controllable Self-assembly Property. Angew. Chem. Int. Ed., 2013, 52, 7781.

35. Ren, H.; Wu, Y.; Li, Y.; Cao, W.; Sun, Z.*; Xu, H.*; Zhang, X.: Visible Light Induced Disruption of Diselenide-Containing LbL Films: Toward Combination of Chemotherapy and Photodynamic Therapy. Small, 2013, 9, 3981.

36. Yi, Y.; Xu, H.*; Wang, L.; Cao, W.; Zhang, X.*: A Novel Dynamic Covalent Bond of Se-N: Towards Controlled Self-Assembly and Disassembly. Chem. Eur. J., 2013, 19, 9506.

37. Cao, W.; Zhang, X.; Miao, X.; Yang, Z.*; Xu, H.*: Gamma-ray Responsive Supramolecular Hydrogel Based on Diselenide-containing Polymer and Peptide. Angew. Chem. Int. Ed., 2013, 52, 6233.

38. Xu, H.*; Cao, W.; Zhang, X.*: Selenium-containing Polymers: Promising Biomaterials for Controlled Release and Enzyme Mimics. Acc. Chem. Res., 2013, 46, 1647.

39. Xu, H.*; Chen, D.; Wang, S.; Zhou, Y.; Sun, J.; Zhang, W.; Zhang, X.*: Macromolecular Self-Assembly and Nanotechnology in China. Phil. Trans. R. Soc. A, 2013, 371, 20120305.

40. Han, P.; Li, S.; Cao, W.; Li, Y.; Sun, Z.; Wang, Z.; Xu, H.*: Red Light Responsive Diselenide-containing Block Copolymer Micelles. J. Mater. Chem. B, 2013, 1, 740.

41. Cao, W.; Li, Y.; Yi, Y.; Ji, S.; Zeng, L.; Sun, Z.*; Xu, H.*: Coordination-Responsive Selenium-Containing Polymer Micelles for Controlled Drug Release. Chem. Sci., 2012, 3, 3403.

42. Yi, Y.; Fa, S.; Cao, W.; Zeng, L.; Wang, M.; Xu, H.*; Zhang, X.: Fabrication of Well-Defined Crystalline Azacalixarene Nanosheets Assisted by Se???N Non-Covalent Interaction. Chem. Commun., 2012, 48, 7495.

43. Li, S.; Han, P.; Xu, H.*: Self-healing Polymeric Materials. (in Chinese) Progress in Chemistry, 2012, 24, 1346.

44. Fu, Y.; Chen, J.; Xu, H.*; Van Oosterwijck, C.; Zhang, X.; Dehaen, W.; Smet, M.*: Fully-branched Hyperbranched Polymers with Diselenide Core as Glutathione Peroxidase Mimics. Macromol. Rapid Commun., 2012, 33, 798. (Invited for Special Issue of Polymer Science: the Next Generation)

45. Xu, H.*; Sch?nhoff, M.; Zhang, X.: Unconventional Layer-by-Layer Assembly: Surface Molecular Imprinting and Its Applications. Small, 2012, 8, 517.

46. Ren, H.; Wu, Y.; Ma, N.; Xu, H.*; Zhang, X.: Side-chain Selenium-Containing Amphiphilic Block Copolymers: Redox-Controlled Self-Assembly and Disassembly. Soft Matter, 2012, 8, 1460. (Top ten most-read Soft Matter articles in December, 2011)

47. Ma, N.; Xu, H.*; An, L.; Li, J.; Sun, Z.; Zhang, X.*: Radiation-Sensitive Diselenide Block Copolymer Micellar Aggregates: Toward the Combination of Radiotherapy and Chemotherapy. Langmuir, 2011, 27, 5874.

48. Han, P.; Ma, N.; Ren, H.; Xu, H.*; Li, Z.; Wang, Z.*; Zhang, X.: Oxidation-Responsive Micelles Based on a Selenium-Containing Polymeric Superamphiphile. Langmuir, 2010, 26, 14414.

49. Ma, N.; Li, Y.; Ren, H.; Xu, H.*; Li, Z.; Zhang, X.*: Selenium-containing Block Copolymers and Their Oxidation-responsive Aggregates. Polym. Chem., 2010, 1, 1609. (Front cover page)

50. Liu, Z.; Yi, Y.; Xu, H.*; Zhang, X.; Ngo, T. H.; Smet, M.: Cation Selective Microcontact Printing Based on Surface Molecular Imprinted Layer-by-Layer Film. Adv. Mater., 2010, 22, 2689. (Highlighted by NPG Asia Materials)

51. Gao, J.; Liu, Y.; Xu, H.*; Wang, Z.; Zhang, X.*: Biostructure-like Surfaces with Thermally Responsive Wettability Prepared by Temperature Induced Phase Separation Micro-molding. Langmuir, 2010, 26, 9673.

52. Ma, N.; Li, Y.; Xu, H.*; Wang, Z.; Zhang, X.*: Dual Redox Responsive Assemblies Formed from Diselenide Block Copolymers. J. Am. Chem. Soc., 2010, 132, 442.

53. Xu, H.*; Huskens, J.*: Versatile Stamps in Microcontact Printing: Transferring Inks by Molecular Recognition and from Ink Reservoirs. Chem. Eur. J., 2010, 16, 2342.

54. Xu, H.*; Gomez-Casado, A.; Liu, Z.; Reinhoudt, D. N.; Lammertink, R. G. H.*; Huskens, J.*: Porous Multilayer-Coated PDMS Stamps for Protein Printing. Langmuir, 2009, 25, 13972.

55. Wang, Y.; Xu, H.; Zhang, X.*: Tuning the Amphiphilicity of Building Blocks: Controlled Self-assembly and Disassembly for Functional Supramolecular Materials. Adv. Mater., 2009, 21, 2849.

56. Gao, J.; Liu, Y.; Xu, H.*; Wang, Z.; Zhang, X.*: Mimicking Biological Structured Surfaces by Phase Separation Micromolding. Langmuir, 2009, 25, 4365.

57. Xu, H.; Ling, X.; van Bennekom, J.; Duan, X.; Ludden, M. J. W.; Reindoudt, D. N.; Wessling, M.; Lammertink, R. G. H.*; Huskens, J.*: Microcontact Printing of Dendrimers, Proteins, and Nanoparticles by Porous Stamps. J. Am. Chem. Soc., 2009, 131, 797.

58. Xu, H.; Wang, Y.; Wang, Z.*; Liu, J.; Smet, M.*; Dehaen, W.: Dendritic Tellurides Act as Antioxidant. Chinese Science Bulletin, 2006, 51, 2315.

59. Xu, H.; Gao, J.; Wang, Y.; Wang, Z.; Smet, M.*; Dehaen, W.; Zhang, X.*: Hyperbranched Polyselenides as Glutathione Peroxidase Mimics. Chem. Commun., 2006, 796.

60. Zhang, X.*; Xu, H.; Dong, Z.; Wang, Y.; Liu, J.*; Shen, J.: Highly Efficient Dendrimer-Based Mimic of Glutathione Peroxidase. J. Am. Chem. Soc., 2004, 126, 10556. (Highlighted by ACS Heart Cut).

 

 

Book chapters

1. Xu, H.; Zhang, X.: Self-assembly of Macromolecules (Chapter 45). in Rapid Development of Chemistry in China: from 1982 to 2012, 2012 Science Press China.

2. Xu, H.; Zhang, X.: Tuning Amphiphilicity of Building Blocks for Controlled Self-assembly and Disassembly: A Way for Fabrication of Functional Supramolecular Materials. in Supramolecular Soft Matter: Applications in Materials and Organic Electronics, (First Edition) 2011 John Wiley & Sons.

3. Xu, H.; Zhang, X.; Cui, S.; Sun, J.: Supramolecular Chemistry: From Molecular Architectures to Functional Assemblies. in Encyclopedia of Life Support Systems (EOLSS):Nanoscience and Nanotechnology, UNESCO-EOLSS, 2009.