喻国灿  助理教授,博士生导师

邮箱:guocanyu@mail.tsinghua.edu.cn

地址:清华大学蒙民伟楼S-513

课题组主页:http://www.supradrug.com/



招生&招聘专业:化学、生物材料、药学药剂、分子生物学、分子影像、细胞代谢、免疫学、医学


教育背景

2010-2015   浙江大学,化学系,博士 (导师:黄飞鹤 教授)

2006-2010   合肥工业大学,化工学院,本科

 

工作履历

2020-            清华大学化学系助理教授

2015-2020  美国国立卫生研究院,博士后(合作导师:Xiaoyuan Shawn Chen教授)


研究领域

课题组主要从事超分子功能材料和超分子诊疗等相关领域的科学研究,致力于开发新型功能材料,应用于疾病的早期诊断与精准治疗。本课题组的研究目标是,聚焦于化学、材料、生物、医学的交叉领域,针对生命科学与临床医学中的重要科学问题,开发前沿纳米生物技术、智能生物材料与器件,为疾病的诊断治疗和药物研发提供新思路新方法。

 

奖励与荣誉

2013 第63届德国林岛诺贝尔奖获得者大会   The 63rd Lindau Nobel Laureate Meeting (Lindau, Germany)

2014 第二届全球青年科学家峰会   The 2nd Global Young Scientists Summit (NTU, Singapore)

2019年和2020年连续入选英国皇家化学会综合类期刊“Top1%高被引中国作者榜单”

2020年入选科睿唯安全球“高被引学者”

 

近期研究成果


1.G. Yu, M. Zhang, M. L. Saha, Z. Mao,* J. Chen, Y. Yao, Z. Zhou, Y. Liu, C. Gao, F. Huang,* X. Chen,* P. J. Stang,* Antitumor Activity of a Unique Polymer That Incorporates a Fluorescent Self-Assembled Metallacycle. J. Am. Chem. Soc. 2017, 139, 15940–15949.

2.G. Yu, X. Zhao, J. Zhou, Z. Mao,* X. Huang, Z. Wang, B. Hua, Y. Liu, F. Zhang, Z. He, O. Jacobson, C. Gao, W. Wang, C. Yu,* X. Zhu, F. Huang,* X. Chen,* Supramolecular Polymer-Based Nanomedicine: High Therapeutic Performance and Negligible Long-Term Immunotoxicity. J. Am. Chem. Soc. 2018, 140, 8005–8019.

3.G. Yu,# Z. Yang,# X. Fu,# B. C. Yung, J. Yang, Z. Mao,* L. Shao, B. Hua, Y. Liu, F. Zhang, Q. Fan,* S. Wang, O. Jacobson, A. Jin, C. Gao, X. Tang, F. Huang,* X. Chen,* Polyrotaxane Based Supramolecular Theranostics. Nat. Commun. 2018, 9, 766.

4.G. Yu, S. Yu, M. L. Saha, J. Zhou, T. R. Cook, B. C. Yung, J. Chen, Z. Mao,* F. Zhang, Z. Zhou, Y. Liu, L. Shao, S. Wang, C. Gao, F. Huang,* P. J. Stang,* X. Chen,* A discrete organoplatinum(II) metallacage as a multimodality theranostic platform for cancer photochemotherapy. Nat. Commun. 2018, 9, 4335.

5.G. Yu,# B. Zhu,# L. Shao,# J. Zhou,# M. L. Saha, B. Shi, Z. Zhang, T. Hong, S. Li,* X. Chen,* P. J. Stang,* Host−guest complexation-mediated codelivery of anticancer drug and photosensitizer for cancer photochemotherapy. Proc. Natl Acad. Sci. USA 2019116, 6618–6623.

6.G. Yu,# T.-Y. Cen,# Z. He,# S.-P. Wang, Z. Wang, X.-W. Ying, S. Li,* O. Jacobson, S. Wang,* L. Wang, L.-S. Lin, R. Tian, Z. Zhou, Q. Ni, X. Li, X. Chen,* Porphyrin Nanocage-Embedded Single Molecular Nanoparticle for Cancer Nanotheranostics. Angew. Chem. Int. Ed. 2019, 58, 8799–8803.

7.J. Zhou, Y. Zhang, G. Yu,* M. R. Crawley, C. R. P. Fulong, A. E. Friedman, S. Sengupta, J. Sun, Q. Li, F. Huang,* T. R. Cook,* Highly Emissive Self-Assembled BODIPY-Platinum Supramolecular Triangles. J. Am. Chem. Soc. 2018, 140, 7730–7736.

8.S. Wang, G. Yu,* Z. Wang, O. Jacobson, R. Tian, L. Lin, F. Zhang, J. Wang,* X. Chen,* Hierarchical Tumor Microenvironment-Responsive Nanomedicine for Enhanced Chemotherapeutic Delivery. Adv. Mater. 2018, 1803926.

9.H. Zhu, H. Wang, B. Shi, W. Tong, G. Yu,* Z. Mao,* F. Huang,* Supramolecular peptide constructed from molecular Lego allowing controllable self-assembly for photodynamic therapy. Nat. Commun. 2019, 10, 2412.

10.S. Wang, G. Yu,* Z. Wang, O. Jacobson, L.-S. Lin, W. Yang, H. Deng, Z. He, Y. Liu, Z.-Y. Chen,* X. Chen,* Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release. Angew. Chem. Int. Ed. 2019, 58, 14758–14763.

11.B. Shi,* Z. Zhou, R. T. Vanderlinden, J.-H. Tang, G. Yu,* K. Acharyya, H. Sepehrpour, P. J. Stang,* Spontaneous Supramolecular Polymerization Driven by Discrete Platinum Metallacycle-Based Host–Guest Complexation. J. Am. Chem. Soc. 2019, 141, 11837–11841.

12.Z. He,# X. Huang,# C. Wang,# X. Li, Y. Liu, Z. Zhou, S. Wang, F. Zhang, Z. Wang, O. Jacobson, J.-J. Zhu,* G. Yu,* Y. Dai,* X. Chen,* A Catalase-Like Metal-Organic Framework Nanohybrid for O2-Evolving Synergistic Chemoradiotherapy. Angew. Chem. Int. Ed. 2019, 58, 8752–8756.

13.J. Zhou, G. Yu,* Q. Li, M. Wang, F. Huang,* Separation of Benzene and Cyclohexane by Nonporous Adaptive Crystals of Hybrid[3]arene. J. Am. Chem. Soc. 2020, 142, 2228–2232.

14.H. Zhu, Q. Li, B. Shi, F. Ge, Y. Liu, Z. Mao, H. Zhu, S. Wang,* G. Yu,* F. Huang,* P. J. Stang,* Dual-Emissive Pt(II) Metallacage with Sensitive Oxygen Response for Imaging of Hypoxia and Imaging-Guided Chemotherapy. Angew. Chem. Int. Ed. 2020, 59, 20208–20214.

15.J. Zhou, G. Yu,* X. Chen,* F. Huang,* Supramolecular cancer nanotheranostics. Chem. Soc. Rev. 2021, 50, 2839–2891