2D9F3

陈永湘 副教授 博士生导师

地址:北京市海淀区清华大学生命科学新馆332    邮编:100084

Email:chen-yx@mail.tsinghua.edu.cn

电话:+86-10-62772259

Web of Science ResearcherID: D-4792-2017

https://www.webofscience.com/wos/author/record/D-4792-2017

ORCID: 0000-0003-3518-0139

课题主页:www.chenyx.group

招生:本课题组每年招收博士生和联合培养硕士生,欢迎推免和报考!

教育背景

2002 - 2007 清华大学化学系,博士

1998 - 2002 湖南大学化学化工学院,学士

工作履历

2011 至今 清华大学化学系,副教授

2007 - 2011 德国马普分子生理所,博士后 (洪堡学者)

研究领域

蛋白质和多肽化学生物学,修饰蛋白质的合成及生物医学功能研究

主讲课程

《有机化学A2》(48学时/学期)

《有机化学H1基础研讨课》(8学时/学期)

《化学生物学》(48学时/学期)

奖励与荣誉

2022  第四届全国高校混合式教学设计创新大赛“设计之星”奖

2020  清华大学第九届青年教师教学大赛一等奖

2019  “中国青年化学家元素周期表”磷元素代言人

2019  国际蛋白质化学合成会议“Rising Star”

2018  中国国际多肽学术会议青年论文奖

2015  Asian Core Program/Advanced Research Network Lectureship Awards

学术兼职:

2019.11至今 Bioorganic Chemistry (Elsevier)  编委

2022.04至今 Journal of Peptide Science (Wiley)  编委

2019.08至今 中国生化制药工业协会 多肽分会专业委员会委员

2023.02至今 International Chemical Biology Society  Scientific Program Committee  委员

学术成果

部分发表论文2016至今,通讯作者文章*):

1. Liu, D.; Liu, Y.; Duan, H.-Z.; Chen, X.; Wang, Y.; Wang, T.; Yu, Q.; Chen, Y.-X.*; Lu, Y.*, Customized synthesis of phosphoprotein bearing phosphoserine or its nonhydrolyzable analog. Synthetic and Systems Biotechnology 2023, 8 (1), 69-78.

2. Duan, H.-Z.; Hu, C.; Li, Y.-L.; Wang, S.-H.; Xia, Y.; Liu, X.*; Wang, J.*; Chen, Y.-X.*, Genetically Encoded Phosphine Ligand for Metalloprotein Design. Journal of the American Chemical Society 2022, 14 (50), 22831-22837.

3. Chang, R.; Chen, J.-L.; Zhang, G.-Y.; Li, Y.; Duan, H.-Z.; Luo, S.-Z.; Chen, Y.-X.*, Intrinsically Disordered Protein Condensate-Modified Surface for Mitigation of Biofouling and Foreign Body Response. Journal of the American Chemical Society 2022, 144 (27), 12147-12157.

4. Chang, R.; Liu, Y.-J.; Zhang, Y.-L.; Zhang, S.-Y.; Han, B.-B.; Chen, F.*; Chen, Y.-X.*, Phosphorylated and Phosphonated Low-Complexity Protein Segments for Biomimetic Mineralization and Repair of Tooth Enamel. Advanced Science 2022, 9(6), 2103829.

5. Wu, J.-J.; Chen, F.-Y.; Han, B.-B.; Zhang, H.-Q.; Zhao, L.; Zhang, Z.-R.; Li, J.-J.; Zhang, B.-D.; Zhang, Y.-N.; Yue, Y.-X.; Hu, H.-G.; Li, W.-H.; Zhang, B.*; Chen, Y.-X.*; Guo, D.-S.*; Li, Y.-M.*, CASTING: A Potent Supramolecular Strategy to Cytosolically Deliver STING Agonist for Cancer Immunotherapy and SARS-CoV-2 Vaccination. CCS Chemistry 2022, DOI: 10.31635/ccschem.022.202201859.

6. Li, Y.; Chang, R.; Chen, Y.-X.*, Recent Advances in Post-polymerization Modifications on Polypeptides: Synthesis and Applications. Chemistry-an Asian Journal 2022, 17(14), e202200318.

7. Hu, J.; Sun, X.-M.; Su, J.-Y.; Zhao, Y.-F.; Chen, Y.-X.*, Different phosphorylation and farnesylation patterns tune Rnd3-14-3-3 interaction in distinct mechanisms. Chemical Science 2021, 12 (12), 4432-4442.

8. Zhu, P.-C.; Chen, Y.-X.*, Facile Synthesis of Boc-Protected Selenocystine and its Compatibility with Late-Stage Farnesylation at Cysteine Site. Protein and Peptide Letters 2021, 28 (6), 603-611.

9. Li, F.-Y.; Zhang, Z.-F.; Voss, S.; Wu, Y.-W.; Zhao, Y.-F.; Li, Y.-M.; Chen, Y.-X.*, Inhibition of K-Ras4B-plasma membrane association with a membrane microdomain-targeting peptide. Chemical Science 2020, 11 (3), 826-832.

10. Duan, H.-Z.; Nie, Z.-K.; Li, Y.; Chen, Y.-X.*, Unremitting progresses for phosphoprotein synthesis. Current Opinion in Chemical Biology 2020, 58, 96-111.

11. Hackenberger, C. P. R.*; Dawson, P. E.*; Chen, Y.-X.*; Hojo, H.*, Modern Peptide and Protein Chemistry: Reaching New Heights. Journal of Organic Chemistry 2020, 85 (3), 1328-1330.

12. Han, B.-B.; Pan, Y.-C.; Li, Y.-M.; Guo, D.-S.*; Chen, Y.-X.*, A host-guest ATP responsive strategy for intracellular delivery of phosphopeptides. Chemical Communications 2020, 56 (41), 5512-5515.

13. Zhang, Y.-L.; Chang, R.; Duan, H.-Z.; Chen, Y.-X.*, Metal ion and light sequentially induced sol-gel-sol transition of a responsive peptide-hydrogel. Soft Matter 2020, 16 (33), 7652-7658.

14. Duan, H.-Z.; Chen, H.-X.; Yu, Q.; Hu, J.; Li, Y.-M.; Chen, Y.-X.*, Stereoselective synthesis of a phosphonate pThr mimetic via palladium-catalyzed gamma-C(sp(3))-H activation for peptide preparation. Organic & Biomolecular Chemistry 2019, 17 (8), 2099-2102.

15. Gao, N.; Huang, Y.-P.; Chu, T.-T.; Li, Q.-Q.; Zhou, B.; Chen, Y.-X.*; Zhao, Y.-F.; Li, Y.-M.*, TDP-43 specific reduction induced by Di-hydrophobic tags conjugated peptides. Bioorganic Chemistry 2019, 84, 254-259.

16. Chen, H.-X.; Kang, J.; Chang, R.; Zhang, Y.-L.; Duan, H.-Z.; Li, Y.-M.; Chen, Y.-X.*, Synthesis of alpha,alpha-Difluorinated Phosphonate pSer/pThr Mimetics via Rhodium-Catalyzed Asymmetric Hydrogenation of beta-Difluorophosphonomethyl alpha-(Acylamino)acrylates. Organic Letters 2018, 20 (11), 3278-3281.

17. Huang, S.-Q.; Han, B.-B.; Li, Y.-M.; Chen, Y.-X.*, A site-specific branching poly-glutamate tag mediates intracellular protein delivery by cationic lipids. Biochemical and Biophysical Research Communications 2018, 503 (2), 671-676.

18. Hu, J.; Zhu, P.; Li, Y.; Chen, Y.-X.*, Synthesis of Ras proteins and their application in biofunctional studies. Chinese Chemical Letters 2018, 29 (7), 1043-1050.

19. Yu, Q.; Sun, J.; Huang, S.; Chang, H.; Bai, Q.; Chen, Y.-X.*; Liang, D.*, Inward Budding and Endocytosis of Membranes Regulated by de Novo Designed Peptides. Langmuir 2018, 34 (21), 6183-6193.

20. Zhang, S.-Y.; Sperlich, B.; Li, F.-Y.; Al-Ayoubi, S.; Chen, H.-X.; Zhao, Y.-F.; Li, Y.-M.; Weise, K.; Winter, R.*; Chen, Y.-X.*, Phosphorylation Weakens but Does Not Inhibit Membrane Binding and Clustering of K-Ras4B. ACS Chemical Biology 2017, 12 (6), 1703-1710.

21. Kang, J.; Chen, H.-X.; Huang, S.-Q.; Zhang, Y.-L.; Li, F.-Y.; Li, Y.-M.; Chen, Y.-X.*, Facile synthesis of Fmoc-protected phosphonate pSer mimetic and its application in assembling a substrate peptide of 14-3-3 zeta. Tetrahedron Letters 2017, 58 (26), 2551-2553.

22. Gao, N.; Chu, T. T.; Li, Q. Q.; Lim, Y. J.; Qiu, T.; Ma, M. R.; Hu, Z. W.; Yang, X. F.; Chen, Y.-X.*; Zhao, Y. F.; Li, Y. M.*, Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau. RSC Advances 2017, 7 (64), 40362-40366.

23. Shi, L.; Chen, H.; Zhang, S. Y.; Chu, T. T.; Zhao, Y. F.; Chen, Y.-X.*; Li, Y. M.*, Semi-synthesis of murine prion protein by native chemical ligation and chemical activation for preparation of polypeptide--thioester. Journal of Peptide Science 2017, 23 (6), 438-444.

24. Chu, T.-T.; Gao, N.; Li, Q.-Q.; Chen, P.-G.; Yang, X.-F.; Chen, Y.-X.*; Zhao, Y.-F.; Li, Y.-M.*, Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation. Cell Chemical Biology 2016, 23 (4), 453-461.

25. Li, L.; Zhang, S.-Y.; Li, Y.-M.; Chen, Y.-X.*, Dual-labeling of ubiquitin proteins by chemoselective reactions for sensing UCH-L3. Molecular Biosystems 2016, 12 (6), 1764-1767.

26. He, Y.-H.; Li, Y.-M.; Chen, Y.-X.*, Phosphorylation regulates proteolytic efficiency of TEV protease detected by a 5(6)-carboxyfluorescein-pyrene based fluorescent sensor. Talanta 2016, 150, 340-345.


部分邀请报告(2016至今):

Young Scholar Forum on Chemical Biology, organized by Professional Committee of Chemical Biology, Chinese Chemical Society, Virtual (2023)

The 14th Australian Peptide Conference, Surfers Paradise, Australia (online talk, 2022)

The 2nd Postdoctoral Annual Academic Conference on Molecular Sciences, Beijing, China (2022)

The 27th American Peptide Symposium, Whistler, Canada (not be able to attend due to pandemic, 2022)

Pacifichem 2021— “Advancing Frontiers in Peptide and Protein Science with Nano-to-Macro Molecular Solutions, New Technologies in Polyamide Synthesis and Applications” symposium, Virtual (2021)

The 16th Chinese International Peptide Symposium, Hefei, China (2020)

The 11th Chinese National Conference on Chemical Biology, Guangzhou, China (2019)

HKU Chemical Biology Symposium 2018, Hongkong, China (2018)

The 7th Sino-German Frontiers of Chemistry Symposium, Munich, Germany (2018)

The 15th Chinese International Peptide Symposium, Shenzhen, China (2018)

The 11th National Conference on Phosphorus Chemistry and Chemical Engineering, Wuhan, China (2017)

Asian Chemical Biology Initiative 2017 Ulaanbaatar Meeting, Ulaanbaatar, Mongolia (2017)

CCS 11th National Symposium on Natural Organic Chemistry, Shanghai, China (2016)