A300


马超,副研究员

北京市海淀区清华大学生物医学馆D206

Email:chaoma_chem@tsinghua.edu.cn


工作及教育经历:

2021- 清华大学化学系 副研究员

2019-2020 美国哈佛大学工程与应用科学学院 博士后

2013-2019 荷兰格罗宁根大学Zernike先进材料研究所 博士

2010-2013 中国药科大学生命科学学院 硕士

2006-2010 中国药科大学生命科学学院 学士


奖励与资助

国家自然科学基金委优秀青年科学基金(2021

国家重点研发计划青年科学家项目(2021

北京市科技新星(2021


研究方向

1. 通过化学生物学、生物合成化学技术,开展蛋白质理性设计,实现高鲁棒性生物材料的组装和宏量制造;

2. 开发生物无机长效纳米技术平台,发展下一代药物递送载体;

3. 借助微生物底盘改造构建稀土细胞工厂,实现资源绿色开采和高值利用。


学术成果

代表论文

1. Shidong Wang, Bo Li, Hongliang Zhang, Jiayin Chen, Xin Sun, Jie Xu, Tingting Ren, Yuanyuan Zhang, Chao Ma*, Wei Guo*, Kai Liu*, Improving Bioavailaibity of Hydrophobic Prodrugs through Supramolecular Nanocarriers Based on Recombinant Proteins for Osteosarcoma Treatment. Angew. Chem. Int. Ed., 2021, 60(20), 11252-11256.

2. Chao Ma#, Jing Sun#, Bo Li#, Yang Feng, Yao Sun, Li Xiang, Baiheng Wu, Lingling Xiao, Baimei Liu, Vladislav S. Petrovskii, Bin Liu, Jinrui Zhang, Zili Wang, Hongyan Li, Lei Zhang, Jingjing Li, Fan Wang, Robert Gӧstl, Igor I. Potemkin, Dong Chen, Hongbo Zeng, Hongjie Zhang, Kai Liu*, Andreas Herrmann*, Ultra-strong bio-glue from genetically engineered polypeptides, Nat. Commun., 2021, 12, 3613.

3. Chao Ma#, Jingjin Dong#, Marco Viviani#, Isotta Tulini, Nicola Pontillo, Sourav Maity, Yu Zhou, Wouter H. Roos, Kai Liu*, Andreas Herrmann*,Giuseppe Portale*, De Novo Rational Design of a Freestanding, Supercharged Polypeptide, Proton-Conducting Membrane. Science Advances, 2020, 6(29): eabc0810.

4. Chao Ma#, Juanjuan Su#, Yao Sun#, Yang Feng, Nolan Shen, Bo Li, Yingxia Liang, Xintong Yang, Hui Wu, Hongjie Zhang, Andreas Herrmann*, Rudolph E. Tanzi, Kai Liu*, Can Zhang*, Significant Upregulation of Alzheimer's Beta-Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides. Angew. Chem. Int. Ed., 2019, 58(51): 18703-18709.

5. Chao Ma#, Bo Li#, Jinrui Zhang#, Yao Sun, Jingjing Li, Hangcheng Zhou, Jianlei Shen, Rui Gu, Jiangchao Qian, Chunhai Fan, Hongjie Zhang, Kai Liu*, Significantly Improving the Bioefficacy for Rheumatoid Arthritis with Supramolecular Nanoformulations. Adv. Mater., 2021: e2100098.

6. Chao Ma, Anke Malessa, Arnold J. Boersma, Kai Liu, Andreas Herrmann*, Supercharged Proteins and Polypeptides. Adv. Mater., 2020: e1905309.

7. Chao Ma, Bo Li, Baiqi Shao, Baiheng Wu, Dong Chen, Juanjuan Su*, Hongjie Zhang, Kai Liu*, Anisotropic Protein Organofibers Encoded with Extraordinary Mechanical Behavior for Cellular Mechanobiology Applications. Angew. Chem. Int. Ed., 2020, 59(48): 21481-21487.

8. Chao Ma#, Juanjuan Su#, Bo Li, Andreas Herrmann, Hongjie Zhang, Kai Liu*, Solvent-Free Plasticity and Programmable Mechanical Behaviors of Engineered Proteins. Adv. Mater., 2020: e1907697.

9. Jing Sun#, Chao Ma#, Sourav Maity#, Fan Wang, Yu Zhou, Giuseppe Portale, Robert Gostl, Wouter H. Roos, Hongjie Zhang, Kai Liu*, Andreas Herrmann*, Reversibly Photo-Modulating Mechanical Stiffness and Toughness of Bioengineered Protein Fibers. Angew. Chem. Int. Ed., 2021, 60(6): 3222-3228.

10. Lei Zhang#, Chao Ma#, Jing Sun, Baiqi Shao, Giuseppe Portale, Dong Chen, Kai Liu*, Andreas Herrmann*, Genetically Engineered Supercharged Polypeptide Fluids: Fast and Persistent Self-Ordering Induced by Touch. Angew. Chem. Int. Ed., 2018, 57(23): 6878-6882.

11. Huige Yang#, Chao Ma#, Kaiyong Li, Kai Liu, Mark Loznik, Rosalie Teeuwen, Jan C. M. Van Hest, Xin Zhou*, Andreas Herrmann*, Jianjun Wang*, Tuning Ice Nucleation with Supercharged Polypeptides. Adv. Mater., 2016, 28(25): 5008-5012.


成果转化

1. 一种基于生物工程蛋白的生物粘合剂及其制备方法,已授权,CN ZL201910778155.0 刘凯,马超,孙静,张洪杰

2. 一种稀土蛋白纤维及其制备方法,已授权,CN ZL201910778135.3 刘凯,马超,孙静,张洪杰

3. 一种高强度的稀土蛋白粘合剂及其制备方法,已授权,CN ZL201910777870.2 刘凯,孙静,马超,张洪杰

4. 一种高粘合强度的生物粘合剂及其制备方法,已授权,CN ZL201910777873.6 刘凯,孙静,马超,张洪杰

5. 光响应蛋白纤维及其制备方法,已授权,CN ZL202010500778.4 刘凯,孙静,马超,张洪杰