瑕瑜 YuXIA

教授,博士生导师

Tel:86-10-62799232

MAIL:xiayu@mail.tsinghua.edu.cn

小组网页:https://www.labxing.com/yuxia

教育背景

1999年获兰州大学学士,2002年获中科院上海药物研究所硕士,2006年获得美国普度大学化学系博士学位。

工作履历

2007-2009年于普度大学分别担任博士后和助理研究员的工作。自2009年秋开始,在普度大学化学系担任助理教授并于2015年担任终身副教授。2016年起任清华化学系教授。

研究领域

生物大分子质谱,气相离子化学,脂质组学

研究概况

瑕瑜教授致力于发展自由基反应质谱系统及其在脂质组学和蛋白组学的应用方法研究。其团队发展了一系列脂质双键位置异构体的定性定量分析方法并积极推动脂质异构体分析在生物医学的应用。在本领域重要期刊包括Nat Commun, PNAS,JACS, Angew Chem, Anal Chem 等发表论文100余篇。2013年获美国质谱学会研究奖,2015-2017年担任美国质谱协会理事会秘书, 2017年获国家优秀青年科学基金资助。现担任国际脂质组学会副主席及Journal of the American Society for Mass Spectrometry (2019-2024)和 International Journal of Mass Spectrometry 期刊编委(2020-2023)。


学术成果

代表性论文:

1. Lin, Q.; Li, P; Fang, M.; Zhang, D.; Xia, Y.*; “Deep-Profiling of Aminophospholipids Reveals Dysregulated Desaturation Pattern in Breast Cancer Cell Line”, Anal. Chem. 2022, 94, 820–828

2. Yang, X.; Zhang, L.; Xia, Y.*; “Photochemical Disulfide-ene Modification Enhances Protein Sequencing and Disulfide Mapping by Mass Spectrometry”, Anal. Chem., 2021, 93, 15231-15235

3. Xia, T.; Yuan, M.; Xu, Y.; Zhou, F.; Yu, K.*; Xia, Y.*; “Deep Structural Annotation of Glycerolipids by Charge-Tagging Paterno−Büchi Reaction and Supercritical Fluid Chromatography−Ion Mobility Mass Spectrometry”, Anal. Chem., 2021, 93, 8345–8353

4. Ma, X.; Zhang, W.; Li, Z.; Xia, Y.*, Z. Ouyang*; “Enabling High Structural Specificity to Lipidomics by Coupling Photochemical Derivatization with Tandem Mass Spectrometry”, Acc. Chem. Res., 2021, 54, 3873–3882

5. Adhikari, S.; Crehuet, R.; Anglada, J. M.*; Francisco, J. S.*; Xia, Y.*; “Two-step Reaction Mechanism Reveals New Antioxidant Capability of Cysteine Disulfides Against Hydroxyl Radical Attack”, Proc. Natl. Acad. Sci. USA, 2020, 117, 18216-18223

6. Zhang, W.; Zhang, D.; Chen, Q.; Wu, J.; Ouyang, Z.*; Xia, Y.*; “Online Photochemical Derivatization Enables Comprehensive Mass Spectrometric Analysis of Unsaturated Phospholipid Isomers, Nat. Commun., 2019, 10, 79

7. Zhao, X.; Zhang, W.; Zhang, D.; Liu, X.; Cao, W.; Chen, Q; Ouyang, Z.; Xia, Y.*; “A Lipidomic Workflow Capable of Resolving sn- and C=C Location Isomers of Phosphatidylcholines”, Chem. Sci., 2019, 10, 10740-10748

8. Ma, X.#; Chong, L.#; Tian, R.; Shi, R.; Hu, T. Y.; Ouyang, Z.*; Xia, Y.*; “Identification and Quantitation of Lipid C=C Location Isomers: A Shotgun Lipidomics Approach Enabled by Photochemical Reaction”, Proc. Natl. Acad. Sci. USA, 2016, 113, 2573-2578

9. Ma, X.; Xia, Y.*; “Pinpointing Double Bonds in Lipids by Paternò–Büchi Reactions and Mass Spectrometry”, Angew. Chem., Int. Ed, 2014, 53, 2592-2596.

10. Love, C. B.; Tan, L.; Francisco, J. S.*; Xia, Y.*; “Competition of Charge- vs. Radical-Directed Fragmentation of Gas-Phase Protonated Cysteine Sulfinyl Radicals”, J. Am. Chem. Soc., 2013, 135, 6226–6233.