喻国灿 副教授，博士生导师
邮箱：guocanyu@mail.tsinghua.edu.cn
地址：清华大学人环楼117
课题组主页：http://www.supradrug.com/
教育背景
2010-2015 浙江大学， 化学系， 博士 (导师：黄飞鹤 教授)
2006-2010 合肥工业大学，化工学院，本科
工作履历
2023- 清华大学化学系， 准聘副教授
2020-2023 清华大学化学系， 助理教授
2015-2020 美国国立卫生研究院， 博士后
研究领域
课题组主要从事新型载体材料的设计及药物/基因递送系统的开发。研究聚焦于化学、材料、生物与医学的交叉领域，围绕生命科学与临床医学中的重要科学问题，开发前沿生物技术、智能生物材料与器件，为疾病的精准治疗及药物研发提供新方法。
奖励与荣誉
2013 第63届德国林岛诺贝尔奖获得者大会 The 63rd Lindau Nobel Laureate Meeting (Lindau, Germany)
2014 第二届全球青年科学家峰会 The 2nd Global Young Scientists Summit (NTU, Singapore)
2019年和2020年连续入选英国皇家化学会综合类期刊“Top1%高被引中国作者榜单”
2020年─2025年连续入选科睿唯安全球“高被引学者”
近期研究成果
#Co-first authors. *Corresponding author.
1. L. Wang,# Q. Zhai,# C. Dong,# W. Zhang, X. Ma, K. Yang, S. Qi, Yarong Wu, G. Yu,* L.-Q. Wang,* G. F. Gao,* Z. Liu,* Split intron-exon system for circular RNA synthesis. Nat. Commun. 2026, 17, 9163.
2. Y. Feng, Y. Yu,* X. Yu, M. Li, J. Lei, Y. Li, Z. Liu,* S. Qi,* G. Yu,* Supramolecular lipid nanoparticle reprograms tumor microenvironment by cucurbit[7]uril-based host–guest recognition for STING-activating cancer immunotherapy. Mater Today 2026, 92, 101–114.
3. J. Lei,# K. Yang,# W. Cao,# S. Qi, X. Du, H. Li, Y. Wang, J. Gan, Y. Feng, Y. Li, W. Zhang, B. Bai, X. Lin, X. Su, Q. Zhang,* T. Liang,* G. Yu,*Pancreatic-targeted lipid nanoparticles based on organ capsule filtration. Nature 2026, 652, 220–229.
4. Y. Feng,# W. Tai,# P. Huang,# S. Qi, X. Yu, M. Li, M. Li, M. Zhang, F. Cao, X. Gao, K. Yang, B. Bai, J. Lei, M. Cheng, Y. Li, G. Cheng,* X. Chen,* G. Yu,* Albumin-recruiting lipid nanoparticle redefines the fate of mRNA vaccines to potentiate the efficacy and safety. Nat. Mater. 2025, 24, 1826–1839.
5. X. Yu#, S. Qi#, W. Cao#, M. Cheng, W. Zhang, Y. Wang, R. Zheng, G. Jin, X. Gao1, M. Lu, J. Lei, K. Peng, X. Su, Q. Zhang,* G. Yu,* Metabolism-programming mRNA-lipid nanoparticle remodels immune microenvironment to empower immunotherapy against MAFLD. Sci. Transl. Med. 2025, 17, eadv2293.
6. X. Yu,# S. Qi,# W. Zhang,# H. Li, F. Cao, Y. Wang, K. Peng, X. Lin,* X. Chen,* G. Yu,* Lipid Nanoparticle Chaperone with Redox-Adaptive Intracellular Microenvironment Modulation Potentiates the Potency of mRNA Vaccines.J. Am. Chem. Soc. 2025, 147, 44072–44086.
7. M. Li, X. Zheng, X. Yu, S. Qi, S. Zhu,* G. Yu,* S. Zhang,* Potentiating the Efficacy of mRNA Vaccines through NIR‐II Imaging-Guided Precise Vaccination. Adv. Sci. 2025, 12, e13014.
8. Y. Li, J. Gan, J. Lei, S. Qi, X. Yu, W. Zhang, Y. Feng, Y. Zhang, M. Cheng, L. Ma,* Z. Mao,* Z. Liu,* G. Yu,* Catalytic Hybrid Lipid Nanoparticles Potentiate Circle RNA-Based Cytokine Immunotherapy. ACS Nano 2025, 19, 7864–7876.
9. W. Tai,*,# C. Tian,# H. Shi,# B. Chai,# X. Yu,# X. Zhuang, P. Dong, M. Li, Q. Yin, S. Feng, W. Wang, O. Zhang, S. Liang, Y. Liu, J. Liu, L. Zhu, G. Zhao,* M. Tian,* G. Yu,* G. Cheng,* An mRNA vaccine against monkeypox virus inhibits infection by co-activation of humoral and cellular immune responses. Nat. Commun. 2025, 16, 2971.
10. M. Cheng,# Z. Jiao,# J. Lei, M. Li, K. Yang, S. Qi, X. Yu, Y. Wang, L.-T. Yan,* G. Yu,* Topologically Engineered Supramolecular Cyclolipid Nanoparticles: A Custom-Tailored Delivery System for Inhaled Combination Therapy. J. Am. Chem. Soc. 2025, 147, 15693–15706.
11. K. Yang,# B. Bai,# X. Li, W. Rou, C. Huang, M. Lu, X. Zhang, C. Dong, S. Qi, Z. Liu,* G. Yu,* Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentiate cancer immunotherapy. Sci. Adv. 2025, 11, eadn7256.
12. J. Gan, J. Lei, Y. Li, M. Lu, X. Yu, G. Yu,* Manganese Oxide-Incorporated Hybrid Lipid Nanoparticles Amplify the Potency of mRNA Vaccine via Oxygen Generation and STING Activation. J. Am. Chem. Soc. 2024, 146, 32689–32700.
13. M. Cheng, X. Yu, S. Qi, K. Yang, M. Lu, F. Cao,* G. Yu,* Development of Organ Targeting Lipid Nanoparticles with Low Immunogenicity and Their Application in the Treatment of Pulmonary Fibrosis. Angew. Chem. Int. Ed. 2024, 63, e202407398.
14. K. Yang,# B. Bai,# J. Lei, X. Yu, S. Qi, Y. Wang, F. Huang, Z. Tong, G. Yu,* Biodegradable Lipid-Modified Poly(Guanidine Thioctic Acid)s: A Fortifier of Lipid Nanoparticles to Promote the Efficacy and Safety of mRNA Cancer Vaccines. J. Am. Chem. Soc. 2024, 146, 11679–11693.
15. J. Chen, W. Zhang, W. Yang, F. Xi, H. He, M. Liang, Q. Dong, J. Hou, M. Wang,* G. Yu,* J. Zhou,* Separation of benzene and toluene associated with vapochromic behaviors by hybrid [4] arene-based co-crystals. Nat. Commun. 2024, 15, 1260.
16. J. Lei,# S. Qi,# X. Yu, X. Gao, K. Yang, X. Zhang, M. Cheng, B. Bai, Y. Feng, M. Lu, Y. Wang, H. Li, G. Yu,* Development of Mannosylated Lipid Nanoparticles for mRNA Cancer Vaccine with High Antigen Presentation Efficiency and Immunomodulatory Capability. Angew. Chem. Int. Ed. 2024, 63,e202318515.
17. M. Yan, S. Wu, Y. Wang, M. Liang, M. Wang, W. Hu, G. Yu,* Z. Mao,* F. Huang,* J. Zhou,* Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions. Adv. Mater. 2024, 36, 2304249.
18. W. Tai,# K. Yang,# Y. Liu,# R. Li,# S. Feng,# B. Chai,# X. Zhuang,# S. Qi, H. Shi, Z. Liu, J. Lei, E. Ma, W. Wang, C. Tian, T. Le, J. Wang, Y. Chen, M. Tian,* Y. Xiang,* G. Yu,* G. Cheng,* A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection. Nat. Commun. 2023, 14, 8042.
19. Y. Feng, S. Qi, X. Yu, X. Zhang, H. Zhu,* G. Yu,* Supramolecular Modulation of Tumor Microenvironment through Pillar[5]arene-Based Host−Guest Recognition to Synergize Cancer Immunotherapy. J. Am. Chem. Soc. 2023, 145, 18789–18799.
20. D. Wu, J. Lei, Z. Zhang, F. Huang,* M. Buljane, G. Yu,* Polymerization in living organisms. Chem. Soc. Rev. 2023, 52, 2911–2945.
