瑕瑜 Yu XIA

教授，博士生导师

Tel：86-10-62799232

MAIL：xiayu@mail.tsinghua.edu.cn

小组网页：https://www.labxing.com/yuxia

教育背景

1999年获兰州大学学士

2002年获中科院上海药物研究所硕士

2006年获得美国普度大学化学系博士学位

工作履历

2009-2017年于普渡大学化学系任助理教授、副教授，现任清华大学化学系教授。

研究领域

生物大分子质谱，气相离子化学，脂质组学

研究概况

瑕瑜教授团队发展了一系列基于自由基化学的生物质谱方法，推动了质谱对生物大分子化学结构的深度解析能力。代表性工作包括建立了对脂质组精细结构鉴定和异构体定量方法，在本领域重要期刊发表论文100余篇，参与撰写章节专著三部。2013年获美国质谱学会的研究奖，2015-2017年担任美国质谱协会理事会秘书, 2017年获得国家优秀青年科学基金资助, 2022 年年获得国家杰出青年科学基金资助。现担任 “Journal of Mass Spectrometry” 编辑和国际脂质组学学会（ILS）副主席，国际质谱学会理事会亚太地区联系人。

学术成果

代表性论文：

1. X. Zhao, J. Liang, Z. Chen, Y. Wang, Z. Guo, W. Zhang, H. Yin, Y. Xia*, “sn-1 Specificity of Lysophosphatidylcholine Acyltransferase-1 Revealed by a Mass Spectrometry-based Assay”, Angew. Chem. Int. Ed., 2023, 62, e202215556

2. W. Zhang, R. Jian, J. Zhao, Y. Liu, Y. Xia*, “Deep-lipidotyping by mass spectrometry: recent technical advances and applications”, J. Lipid Res., 2022, 63,100219

3. X. Ma, W. Zhang, Z. Li, Y. Xia*, Z. Ouyang*, “Enabling High Structural Specificity to Lipidomics by Coupling Photochemical Derivatization with Tandem Mass Spectrometry”, Acc. Chem. Res., 2021, 54, 3873–3882

4. X. Yang, L. Zhang, Y. Xia*, “Photochemical Disulfide-ene Modification Enhances Protein Sequencing and Disulfide Mapping by Mass Spectrometry”, Anal. Chem., 2021, 93, 15231-15235

5. S. Adhikari, R. Crehuet, J.M. Anglada*, J.S. Francisco*, Y. Xia*, “Two-Step Reaction Mechanism Reveals New Antioxidant Capability of Cysteine Disulfides against Hydroxyl Radical Attack”, Proc. Natl. Acad. Sci. USA, 2020, 117, 18216-18223

6. X. Zhao, W. Zhang, D. Zhang, X. Liu, W. Cao, Q. Chen, Z. Ouyang, Y. Xia*, “A Lipidomic Workflow Capable of Resolving sn- and C=C Location Isomers of Phosphatidylcholines”, Chem. Sci., 2019, 10, 10740-10748

7. W. Zhang, D. Zhang, Q. Chen, J. Wu, Z. Ouyang*, Y. Xia* “Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers” Nat. Commun., 2019, 10, 79-07963

8. S. Adhikari, X. Yang, Y. Xia*, “Acetone/Isopropanol Photoinitiating System Enables Tunable Disulfide Reduction and Disulfide Mapping via Tandem Mass Spectrometry”, Anal. Chem. 2018, 90, 13036-13043

9. X. Ma, L. Chong, R. Tian, R. Shi, T. Y. Hu, Z. Ouyang*, Y. Xia*, “Identification and quantitation of lipid C=C location isomers: a shotgun lipidomics approach enabled by photochemical reaction”, Proc. Natl. Acad. Sci. USA, 2016, 113, 2573-2578.

10. X. Ma and Y. Xia*, “Pinpointing Double Bonds in Lipids by Paternò–Büchi Reactions and Mass Spectrometry”, Angew. Chem., Int. Ed, 2014, 53, 2592-2596.