Lei JIAO
Associate Professor
Center of Basic Molecular Science (CBMS), Department of Chemistry
RM S907, Mong Man Wai Building of Science and Technology
Tel: 86-10-62788874
Email: leijiao@mail.tsinghua.edu.cn
Website: www.jiaolei.group
Educational Background
2001-2005 Peking University, College of Chemistry and Molecular Engineering, BS
2005-2010 Peking University, College of Chemistry and Molecular Engineering, PhD
Professional Experience
2010-2013 Technical University Munich, Department of Chemistry, Postdoctoral Fellow
2014-2022 Tsinghua University, Department of Chemistry, Associate Professor (tenure-track)
2022- Tsinghua University, Department of Chemistry, Associate Professor w/ tenure
Honors and Awards
2023 Young Investigator Award in Physical Organic Chemistry, Chinese Chemical Society (2023)
2017 Newcomer Award in Physical Organic Chemistry, Chinese Chemical Society (2017).
2015 Qiu Shi Outstanding Young Scholar Award
2014 Thieme Chemistry Journals Award
2012 National Excellent PhD Thesis Award
2010 Eli Lilly Asia Outstanding Graduate Thesis Award (First Place)
Academic Service
Professional Committee of Physical Organic Chemistry, Chinese Chemical Society (2019-)
SYNTHESIS International Advisory Board (2023-)
Research Interessts
The Jiao group focuses on mechanistic studies using physical organic methods to solve fundamental problems in organic chemistry, and to tackle challenges of organic synthesis by rational molecular design. The current research interests include N-boryl pyridyl anion chemistry and design of cooperative ligands for Pd catalysis.
Representative Publications
1. Qi, J.-Q.; Suo, W.; Liu, J.; Sun, S.; Jiao, L.*; Guo, X.* Direct Observation of All Open-Shell Intermediates in a Photocatalytic Cycle. J. Am. Chem. Soc. 2024, 146, 7140-7145.
2. Bai, L.; Jiao, L.* Modular Photoredox System with Extreme Reduction Potentials Based on Pyridine Catalysis. Chem 2023, 9, 3245-3267.
3. Wang, F.-Y.; Li, Y.-X.; Jiao, L.* Functionalized Cycloolefin Ligand as a Solution to Ortho-Constraint in the Catellani-Type Reaction. J. Am. Chem. Soc. 2023, 145, 4871-4881.
4. Yuan, C.-H.; Wang, X.-X.; Jiao, L.* Ligand-Enabled Pd(II)-Catalyzed Enantioselective β-C(sp3)-H Arylation of Aliphatic Tertiary Amides. Angew. Chem. Int. Ed. 2023, 62, e202300854.
5. Zheng, Y.-X.; Jiao, L.* Hybrid Cycloolefin Ligands for Palladium/Olefin Cooperative Catalysis. Nat. Synth. 2022, 1, 180-187.
6. Gao, D.; Jiao, L.* Divergent Synthesis of Indolenine and Indoline Ring Systems by Palladium-Catalyzed Asymmetric Dearomatization of Indoles. Angew. Chem. Int. Ed. 2022, 61, e202116024.
7. Zhou, F.-Y.; Jiao, L.* Asymmetric Defluoroallylation of 4-Trifluoromethylpyridines Enabled by Umpolung C-F Bond Activation. Angew. Chem. Int. Ed. 2022, 61, e202201102.
8. Wang, F.-Y.; Jiao, L.* Total Synthesis of (-)-Arborisidine. Angew. Chem. Int. Ed. 2021, 60, 12732-12736.
9. Zhang, L.; Wu, Z.-Q.; Jiao, L.* Photoinduced Radical Borylation of Alkyl Bromides Catalyzed by 4-Phenylpyridine. Angew. Chem. Int. Ed. 2020, 59, 2095-2099.
10. Zhang, L.; Jiao, L.* Visible-Light-Induced Organocatalytic Borylation of Aryl Chlorides. J. Am. Chem. Soc. 2019, 141, 9124–9128.
11. Zhang, L.; Jiao, L.* Pyridine-Catalyzed Radical Borylation of Aryl Halides. J. Am. Chem. Soc. 2017, 139, 607–610.
12. Zhang, L.; Yang, H.; Jiao, L.* Revisiting the Radical Initiation Mechanism of the Diamine-Promoted Transition-Metal-Free Cross-Coupling Reaction. J. Am. Chem. Soc. 2016, 138, 7151-7160.
13. Zhang, Z.-X.; Chen, S.-C.; Jiao, L.* Total Synthesis of (+)-Minfiensine: Construction of the Tetracyclic Core Structure by an Asymmetric Cascade Cyclization. Angew. Chem. Int. Ed. 2016, 55, 8090-8094.
