Professor Yu Xia
Contact: Department of Chemistry, Tsinghua University, Beijing 100084, China
Office: Rm. S505 Mengminwei Technology Building
Tel.: +86-10-62799232
Email: xiayu@mail.tsinghua.edu.cn
Group website: https://www.labxing.com/yuxia
Biography:
Yu Xia earned her B.S. (1999) in Chemistry from Lanzhou University, China, M.S. (2002) from Shanghai Institute of Material Medical, CASs, China, and Ph.D. (2006) under the supervision of Professor Scott A. McLuckey from Purdue University, USA. After postdoctoral training with Professor Graham R. Cooks at Purdue, Dr. Xia took positions as an Assistant and Associate Professor at the Department of Chemistry, Purdue University (2009-2017). She joined Tsinghua University as a Professor of the Department of Chemistry in 2016. Dr. Xia utilizes radical chemistry as a unique approach to achieve enhanced bioanalysis via mass spectrometry. Her recent research emphasizes on developing lipidomic tools capable of resolving structural isomers. Her work has resulted in over 100 peer-reviewed publications and book chapters. She currently serves as an Associate Editor for the Journal of Mass Spectrometry and the Vice President for Diversity and Inclusion of the International Lipidomics Society.
Research Area:
Bio-analysis, Mass spectrometry, Lipidomics
Teaching:
Spectral Interpretation for Organic Compounds (2 credits, undergrad course)
Spectroscopic Methods in Organic Chemistry (3 credits, graduate course)
Representative Publications:
1. Lin, Q.; Li, P; Fang, M.; Zhang, D.; Xia, Y.*; “Deep-Profiling of Aminophospholipids Reveals Dysregulated Desaturation Pattern in Breast Cancer Cell Line”, Anal. Chem. 2022, 94, 820–828
2. Yang, X.; Zhang, L.; Xia, Y.*; “Photochemical Disulfide-ene Modification Enhances Protein Sequencing and Disulfide Mapping by Mass Spectrometry”, Anal. Chem., 2021, 93, 15231-15235
3. Xia, T.; Yuan, M.; Xu, Y.; Zhou, F.; Yu, K.*; Xia, Y.*; “Deep Structural Annotation of Glycerolipids by Charge-Tagging Paterno−Büchi Reaction and Supercritical Fluid Chromatography−Ion Mobility Mass Spectrometry”, Anal. Chem., 2021, 93, 8345–8353
4. Ma, X.; Zhang, W.; Li, Z.; Xia, Y.*, Z. Ouyang*; “Enabling High Structural Specificity to Lipidomics by Coupling Photochemical Derivatization with Tandem Mass Spectrometry”, Acc. Chem. Res., 2021, 54, 3873–3882
5. Adhikari, S.; Crehuet, R.; Anglada, J. M.*; Francisco, J. S.*; Xia, Y.*; “Two-step Reaction Mechanism Reveals New Antioxidant Capability of Cysteine Disulfides Against Hydroxyl Radical Attack”, Proc. Natl. Acad. Sci. USA, 2020, 117, 18216-18223
6. Zhang, W.; Zhang, D.; Chen, Q.; Wu, J.; Ouyang, Z.*; Xia, Y.*; “Online Photochemical Derivatization Enables Comprehensive Mass Spectrometric Analysis of Unsaturated Phospholipid Isomers, Nat. Commun., 2019, 10, 79
7. Zhao, X.; Zhang, W.; Zhang, D.; Liu, X.; Cao, W.; Chen, Q; Ouyang, Z.; Xia, Y.*; “A Lipidomic Workflow Capable of Resolving sn- and C=C Location Isomers of Phosphatidylcholines”, Chem. Sci., 2019, 10, 10740-10748
8. Ma, X.#; Chong, L.#; Tian, R.; Shi, R.; Hu, T. Y.; Ouyang, Z.*; Xia, Y.*; “Identification and Quantitation of Lipid C=C Location Isomers: A Shotgun Lipidomics Approach Enabled by Photochemical Reaction”, Proc. Natl. Acad. Sci. USA, 2016, 113, 2573-2578
9. Ma, X.; Xia, Y.*; “Pinpointing Double Bonds in Lipids by Paternò–Büchi Reactions and Mass Spectrometry”, Angew. Chem., Int. Ed, 2014, 53, 2592-2596.
10. Love, C. B.; Tan, L.; Francisco, J. S.*; Xia, Y.*; “Competition of Charge- vs. Radical-Directed Fragmentation of Gas-Phase Protonated Cysteine Sulfinyl Radicals”, J. Am. Chem. Soc., 2013, 135, 6226–6233.