Professor Yu Xia

Contact: Department of Chemistry, Tsinghua University, Beijing 100084, China

Office: Rm. S505 Mengminwei Technology Building

Tel.: +86-10-62799232


Group website:


Dr. Yu Xia earned her B.S. (1999) in Chemistry from Lanzhou University, China, M.S. (2002) from Shanghai Institute of Material Medical, CASs, China, and Ph.D. (2006) under the supervision of Professor Scott A. McLuckey from Purdue University, USA. After postdoctoral training with Prof. Graham R. Cooks at Purdue, Dr. Xia took positions as Assistant and Associate Professor at the Department of Chemistry, Purdue University (2009-2017). She is currently a Professor at the Department of Chemistry, Tsinghua University, Beijing, China. Dr. Xia utilizes radical chemistry as a unique approach to achieve enhanced bioanalysis via mass spectrometry. In particular, her recent research emphasizes on developing lipidomic tools capable of resolving structural isomers. Her work has resulted in over 90 peer-reviewed publications and book chapters. Dr. Xia received ASMS Research Award (2013) and served as the Secretary of ASMS from 2015-2017. She currently serves on the editorial board of the Journal of the American Society of Mass Spectrometry and International Journal of Mass Spectrometry.

Research Area:

Bio-analysis, Mass spectrometry, Lipidomics


Spectral Interpretation for Organic Compounds (2 credits, undergrad course)

Spectroscopic Methods in Organic Chemistry (3 credits, graduate course)

Representative Publications:

1.X. Xie, J. Zhao, M. Lin, J.-L. Zhang, Y. Xia*, “Profiling of Cholesteryl Esters by Coupling Charge Tagging Paternò-Büchi Reaction and Liquid Chromatography-Mass Spectrometry” Anal. Chem. 2020, 92, 8487–8496
2.W. Zhang*, B. Shang, Z. Ouyang, Y. Xia*, “Enhanced phospholipid isomer analysis by online photochemical derivatization and RPLC-MS”, Anal. Chem. 2020, 92, 6719-6726
3.X. Zhao, W. Zhang, D. Zhang, X. Liu, W. Cao, Q. Chen, Z. Ouyang, Y. Xia*, “A Lipidomic Workflow Capable of Resolving sn- and C=C Location Isomers of Phosphatidylcholines”, Chem. Sci., 2019, 10, 10740-10748
4.W. Zhang, D. Zhang, Q. Chen, J. Wu, Z. Ouyang*, Y. Xia* “Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers” Nat. Commun., 2019, 10, 79-07963
5.S. Adhikari, X. Yang, Y. Xia*, “Acetone/Isopropanol Photoinitiating System Enables Tunable Disulfide Reduction and Disulfide Mapping via Tandem Mass Spectrometry”, Anal. Chem. 2018, 90, 13036-13043
6.S. Adhikari, W. Zhang, X. Xie, Q. Chen, Y. Xia*, “Shotgun Analysis of Diacylglycerols Enabled by Thiol-ene Click Chemistry”, Anal. Chem. 2018, 90, 5239-5246
7.X. Ma, L. Chong, R. Tian, R. Shi, T. Y. Hu, Z. Ouyang*, Y. Xia*, “Identification and quantitation of lipid C=C location isomers: a shotgun lipidomics approach enabled by photochemical reaction”, Proc. Natl. Acad. Sci. USA, 2016, 113, 2573-2578.
8.X. Ma and Y. Xia*, “Pinpointing Double Bonds in Lipids by Paternò–Büchi Reactions and Mass Spectrometry”, Angew. Chem., Int. Ed, 2014, 53, 2592-2596.
9.L. Tan, H. Hu, J.S. Francisco*, and Y. Xia*, "A Mass Spectrometric Approach for Probing the Stability of Bioorganic Radicals", Angew. Chem., Int. Ed., 2014, 53, 1887-1890.
10.C. B. Love, L. Tan, J. S. Francisco*, and Y. Xia*, “Competition of Charge- vs. Radical-Directed Fragmentation of Gas-Phase Protonated Cysteine Sulfinyl Radicals”, J. Am. Chem. Soc., 2013, 135, 6226–6233.