Professor Yu Xia

Contact: Department of Chemistry, Tsinghua University, Beijing 100084, China

Office: Rm. S505 Mengminwei Technology Building

Tel.: +86-10-62799232


Group website:


Yu Xia earned her B.S. (1999) in Chemistry from Lanzhou University, China, M.S. (2002) from Shanghai Institute of Material Medical, CASs, China, and Ph.D. (2006) under the supervision of Professor Scott A. McLuckey from Purdue University, USA. After postdoctoral training with Professor Graham R. Cooks at Purdue, Dr. Xia took positions as an Assistant and Associate Professor at the Department of Chemistry, Purdue University (2009-2017). She joined Tsinghua University as a Professor of the Department of Chemistry in 2016. Dr. Xia utilizes radical chemistry as a unique approach to achieve enhanced bioanalysis via mass spectrometry. Her recent research emphasizes on developing lipidomic tools capable of resolving structural isomers. Her work has resulted in over 100 peer-reviewed publications and book chapters. She currently serves as an Associate Editor for the Journal of Mass Spectrometry and the Vice President for Diversity and Inclusion of the International Lipidomics Society.

Research Area:

Bio-analysis, Mass spectrometry, Lipidomics


Spectral Interpretation for Organic Compounds (2 credits, undergrad course)

Spectroscopic Methods in Organic Chemistry (3 credits, graduate course)

Representative Publications:

1. X. Zhao, J. Liang, Z. Chen, Y. Wang, Z. Guo, W. Zhang, H. Yin, Y. Xia*, “sn-1 Specificity of Lysophosphatidylcholine Acyltransferase-1 Revealed by a Mass Spectrometry-based Assay”, Angew. Chem. Int. Ed., 2023, 62, e202215556

2. W. Zhang, R. Jian, J. Zhao, Y. Liu, Y. Xia*, “Deep-lipidotyping by mass spectrometry: recent technical advances and applications”, J. Lipid Res., 2022, 63,100219

3. X. Ma, W. Zhang, Z. Li, Y. Xia*, Z. Ouyang*, “Enabling High Structural Specificity to Lipidomics by Coupling Photochemical Derivatization with Tandem Mass Spectrometry”, Acc. Chem. Res., 2021, 54, 3873–3882

4. X. Yang, L. Zhang, Y. Xia*, “Photochemical Disulfide-ene Modification Enhances Protein Sequencing and Disulfide Mapping by Mass Spectrometry”, Anal. Chem., 2021, 93, 15231-15235

5. S. Adhikari, R. Crehuet, J.M. Anglada*, J.S. Francisco*, Y. Xia*, “Two-Step Reaction Mechanism Reveals New Antioxidant Capability of Cysteine Disulfides against Hydroxyl Radical Attack”, Proc. Natl. Acad. Sci. USA, 2020, 117, 18216-18223

6. X. Zhao, W. Zhang, D. Zhang, X. Liu, W. Cao, Q. Chen, Z. Ouyang, Y. Xia*, “A Lipidomic Workflow Capable of Resolving sn- and C=C Location Isomers of Phosphatidylcholines”, Chem. Sci., 2019, 10, 10740-10748

7. W. Zhang, D. Zhang, Q. Chen, J. Wu, Z. Ouyang*, Y. Xia* “Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers” Nat. Commun., 2019, 10, 79-07963

8. S. Adhikari, X. Yang, Y. Xia*, “Acetone/Isopropanol Photoinitiating System Enables Tunable Disulfide Reduction and Disulfide Mapping via Tandem Mass Spectrometry”, Anal. Chem. 2018, 90, 13036-13043

9. X. Ma, L. Chong, R. Tian, R. Shi, T. Y. Hu, Z. Ouyang*, Y. Xia*, “Identification and quantitation of lipid C=C location isomers: a shotgun lipidomics approach enabled by photochemical reaction”, Proc. Natl. Acad. Sci. USA, 2016, 113, 2573-2578.

10. X. Ma and Y. Xia*, “Pinpointing Double Bonds in Lipids by Paternò–Büchi Reactions and Mass Spectrometry”, Angew. Chem., Int. Ed, 2014, 53, 2592-2596.