Prof. Yanmei LI , Ph.D

Department of Chemistry, Tsinghua University, Beijing 100084, P.R.China

Tel: 008610-62772259

Fax: 008610-62781695



1982.9-1987.7 Department of Chemistry, TsinghuaUniversity

Bachelor of Science (Honours in Chemistry)

1987.9-1989.12 Department of Chemistry, TsinghuaUniversity

Master of Science

1989.12-1992.7 Department of Chemistry, TsinghuaUniversity

Doctor of Philosophy


1992.7-1993.12 Department of Chemistry, TsinghuaUniversity Lecturer

1993.12-1998.8 Department of Chemistry, TsinghuaUniversity Associate Professor

1996.10-1997.10 Institute of Organic Chemistry, University of Karlsruhe, Germany Postdoctor

1998.8-present Department of Chemistry, TsinghuaUniversity Professor


1.Chemical synthetic vaccine

2.Pattern recognition receptor agonist

3.Novel adjuvant for COVID-19 vaccines

4.Protein chemical modification

5.Modified protein synthesis

6.The influence of post-translational modification on neurodegenerative disease-related proteins

7.Strategies for inhibiting the precipitation of proteins related to neurodegenerative diseases


1. Li, Wen-Hao; Li, Yan-Mei* “Chemical Strategies to Boost Cancer Vaccines.” Chem. Rev. 2020, 120, 11420-11478.

2. Zhao, Kun#; Lim, Yeh-Jun#; Liu, Zhenying#; Long, Houfang; Sun, Yunpeng; Hu, Jin-Jian; Zhao, Chunyu; Tao, Youqi; Zhang, Xing; Li, Dan; Li, Yan-Mei*; Liu, Cong* “Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM.” Proc. Natl. Acad. Sci. USA 2020, 117, 20305–20315.

3. Li, Qian-Qian; Chen, Pu-Guang; Hu, Zhi-Wen; Cao, Yuan; Chen, Liang-Xiao; Chen, Yong-Xiang; Zhao, Yu-Fen; Li, Yan-Mei* “Selective inhibition of cancer cells by enzyme-induced gain of function of phosphorylated melittin analogues.” Chem. Sci.,2017,8,7675–7681.

4. Cai, Hui; Sun, Zhan-Yi; Chen, Mei-Sha; Zhao, Yu-Fen; Kunz, Horst*; Li, Yan-Mei* “Synthetic Multivalent Glycopeptide-Lipopeptide Antitumor Vaccines: Impact of the Cluster Effect on the Killing of Tumor Cells.” Angew. Chem. Int. Ed. 2014, 53, 1699 –1703.

5. Cai, Hui; Chen, Mei-Sha; Sun, Zhan-Yi; Zhao, Yu-Fen; Kunz, Horst*; Li, Yan-Mei* “Self-Adjuvanting Synthetic Antitumor Vaccines from MUC1 Glycopeptides Conjugated to T-Cell Epitopes from Tetanus Toxoid.” Angew. Chem. Int. Ed. 2013, 52, 6106 –6110.

6. Huang, Zhi-Hua; Shi, Lei; Ma, Jing-Wen; Sun, Zhan-Yi; Cai, Hui; Chen, Yong-Xiang; Zhao, Yu-Fen; Li, Yan-Mei* “A Totally Synthetic, Self-Assembling, Adjuvant-Free MUC1 Glycopeptide Vaccine for Cancer Therapy.” J. Am. Chem. Soc. 2012, 134, 21, 8730-8733.

7. Cai, Hui#; Huang, Zhi-Hua#; Shi, Lei; Sun, Zhan-Yi; Zhao, Yu-Fen; Kunz, Horst*; Li, Yan-Mei* “Variation of the Glycosylation Pattern in MUC1 Glycopeptide BSA Vaccines and Its Influence on the Immune Response.” Angew. Chem. Int. Ed. 2012, 51, 1719–1723.

8. Kaiser, Anton; Gaidzik, Nikola; Becker, Torsten; Menge, Clara; Groh, Kai; Cai, Hui; Li, Yan-Mei; Gerlitzki, Bastian; Schmitt, Edgar; Kunz, Horst* “Fully Synthetic Vaccines Consisting of Tumor-Associated MUC1 Glycopeptides and a Lipopeptide Ligand of the Toll-like Receptor 2.” Angew. Chem. Int. Ed. 2010, 49, 3688–3692.

9. Du, Jin-Tang; Li, Yan-Mei*; Wei, Wei; Wu, Guo-Shi; Zhao, Yu-Fen; Kanazawa, Kenji; Nemoto, Tadashi; Nakanishi, Hiroshi “Low-barrier hydrogen bond between phosphate and the amide group in phosphopeptide.” J. Am. Chem. Soc. 2005,127, 16350-16351.