Guocan Yu

Assistant Professor

Research Group Homepage

Dr. Guocan Yu received his BS degree in polymer materials and engineering from Hefei University of Technology in 2010. He received his PhD in Chemistry from the Zhejiang University in 2015 under the mentorship of Prof. Feihe Huang. Then he joined Dr. Xiaoyuan (Shawn) Chen’s Laboratory of Molecular Imaging and Nanomedicine (LOMIN) at the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), as a postdoctoral research fellow. He joined the Department of Chemistry at Tsinghua University to start his independent research career in the late of 2020 as an assistant professor. His current research interests are mainly focused on supramolecular functional materials and supramolecular theranostics. He was continuously ranked in the “Top 1% Highly Cited Chinese Author List” in general chemistry group portfolio of RSC journals in 2019 and 2020. He was also selected as a “2020 Highly Cited Researcher” by Clarivate Analytics.


2010/09 – 2015/06  Zhejiang University Ph.D.

2006/09 – 2010/06  Hefei University of Technology B.Sc.

Professional Experience

2020/12 – current   Tsinghua University, Assistant Professor

2015/09 – 2020/09  National Institutes of Health, Research Fellow

Research interests

1. Supramolecular theranostics

2. Smart nanomedicines for cardiovascular diseases

3. Cancer immunotherapy

Recent Publications

1.G. Yu, M. Zhang, M. L. Saha, Z. Mao,* J. Chen, Y. Yao, Z. Zhou, Y. Liu, C. Gao, F. Huang,* X. Chen,* P. J. Stang,* Antitumor Activity of a Unique Polymer That Incorporates a Fluorescent Self-Assembled Metallacycle. J. Am. Chem. Soc. 2017, 139, 15940–15949.

2.G. Yu, X. Zhao, J. Zhou, Z. Mao,* X. Huang, Z. Wang, B. Hua, Y. Liu, F. Zhang, Z. He, O. Jacobson, C. Gao, W. Wang, C. Yu,* X. Zhu, F. Huang,* X. Chen,* Supramolecular Polymer-Based Nanomedicine: High Therapeutic Performance and Negligible Long-Term Immunotoxicity. J. Am. Chem. Soc. 2018, 140, 8005–8019.

3.G. Yu,# Z. Yang,# X. Fu,# B. C. Yung, J. Yang, Z. Mao,* L. Shao, B. Hua, Y. Liu, F. Zhang, Q. Fan,* S. Wang, O. Jacobson, A. Jin, C. Gao, X. Tang, F. Huang,* X. Chen,* Polyrotaxane Based Supramolecular Theranostics. Nat. Commun. 2018, 9, 766.

4.G. Yu, S. Yu, M. L. Saha, J. Zhou, T. R. Cook, B. C. Yung, J. Chen, Z. Mao,* F. Zhang, Z. Zhou, Y. Liu, L. Shao, S. Wang, C. Gao, F. Huang,* P. J. Stang,* X. Chen,* A discrete organoplatinum(II) metallacage as a multimodality theranostic platform for cancer photochemotherapy. Nat. Commun. 2018, 9, 4335.

5.J. Zhou, Y. Zhang, G. Yu,* M. R. Crawley, C. R. P. Fulong, A. E. Friedman, S. Sengupta, J. Sun, Q. Li, F. Huang,* T. R. Cook,* Highly Emissive Self-Assembled BODIPY-Platinum Supramolecular Triangles. J. Am. Chem. Soc. 2018, 140, 7730–7736.

6.S. Wang, G. Yu,* Z. Wang, O. Jacobson, R. Tian, L. Lin, F. Zhang, J. Wang,* X. Chen,* Hierarchical Tumor Microenvironment-Responsive Nanomedicine for Enhanced Chemotherapeutic Delivery. Adv. Mater. 2018, 1803926.

7.G. Yu,# B. Zhu,# L. Shao,# J. Zhou,# M. L. Saha, B. Shi, Z. Zhang, T. Hong, S. Li,* X. Chen,* P. J. Stang,* Host−guest complexation-mediated codelivery of anticancer drug and photosensitizer for cancer photochemotherapy. Proc. Natl Acad. Sci. USA 2019116, 6618–6623.

8.G. Yu,# T.-Y. Cen,# Z. He,# S.-P. Wang, Z. Wang, X.-W. Ying, S. Li,* O. Jacobson, S. Wang,* L. Wang, L.-S. Lin, R. Tian, Z. Zhou, Q. Ni, X. Li, X. Chen,* Porphyrin Nanocage-Embedded Single Molecular Nanoparticle for Cancer Nanotheranostics. Angew. Chem. Int. Ed. 2019, 58, 8799–8803.

9.H. Zhu, H. Wang, B. Shi, W. Tong, G. Yu,* Z. Mao,* F. Huang,* Supramolecular peptide constructed from molecular Lego allowing controllable self-assembly for photodynamic therapy. Nat. Commun. 2019, 10, 2412.

10.S. Wang, G. Yu,* Z. Wang, O. Jacobson, L.-S. Lin, W. Yang, H. Deng, Z. He, Y. Liu, Z.-Y. Chen,* X. Chen,* Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release. Angew. Chem. Int. Ed. 2019, 58, 14758–14763.

11.B. Shi,* Z. Zhou, R. T. Vanderlinden, J.-H. Tang, G. Yu,* K. Acharyya, H. Sepehrpour, P. J. Stang,* Spontaneous Supramolecular Polymerization Driven by Discrete Platinum Metallacycle-Based Host–Guest Complexation. J. Am. Chem. Soc. 2019, 141, 11837–11841.

12.Z. He,# X. Huang,# C. Wang,# X. Li, Y. Liu, Z. Zhou, S. Wang, F. Zhang, Z. Wang, O. Jacobson, J.-J. Zhu,* G. Yu,* Y. Dai,* X. Chen,* A Catalase-Like Metal-Organic Framework Nanohybrid for O2-Evolving Synergistic Chemoradiotherapy. Angew. Chem. Int. Ed. 2019, 58, 8752–8756.

13.J. Zhou, G. Yu,* Q. Li, M. Wang, F. Huang,* Separation of Benzene and Cyclohexane by Nonporous Adaptive Crystals of Hybrid[3]arene. J. Am. Chem. Soc. 2020, 142, 2228–2232.

14.H. Zhu, Q. Li, B. Shi, F. Ge, Y. Liu, Z. Mao, H. Zhu, S. Wang,* G. Yu,* F. Huang,* P. J. Stang,* Dual-Emissive Pt(II) Metallacage with Sensitive Oxygen Response for Imaging of Hypoxia and Imaging-Guided Chemotherapy. Angew. Chem. Int. Ed. 2020, 59, 20208–20214.

15.J. Zhou, G. Yu,* X. Chen,* F. Huang,* Supramolecular cancer nanotheranostics. Chem. Soc. Rev. 2021, 50, 2839–2891