Professor Yu Xia

Contact: Department of Chemistry, Tsinghua University, Beijing 100084, China

Office: Rm. S505 Mengminwei Technology Building

Tel.: +86-10-62799232

Email: xiayu@mail.tsinghua.edu.cn

Group website: https://www.labxing.com/yuxia


Biography:

Dr. Yu Xia earned her B.S. (1999) in Chemistry from Lanzhou University, China, M.S. (2002) from Shanghai Institute of Material Medical, CASs, China, and Ph.D. (2006) under the supervision of Professor Scott A. McLuckey from Purdue University, USA. After postdoctoral training with Professor Graham R. Cooks at Purdue, Dr. Xia took positions as Assistant and Associate Professor at the Department of Chemistry, Purdue University (2009-2017). She joined the Department of Chemistry, Tsinghua University as a Professor afterwards. Her research directions include the development of radical reaction mass spectrometry systems and methods for lipidomics and proteomics applications. Her work has resulted in over 100 peer-reviewed publications and book chapters. Dr. Xia received ASMS Research Award (2013) and served as the Secretary of ASMS (2015-2017). She received the support from the National Natural Science Foundation for Excellent Young Scholar (2017). She is the Vice President for Diversity and Inclusion of the International Lipidomics Society and currently serves on the editorial boards of the Journal of the American Society for Mass Spectrometry2019-2024and International Journal of Mass Spectrometry (2020-2023), respectively.


Research Area:

Bio-analysis, Mass spectrometry, Lipidomics


Teaching:

Spectral Interpretation for Organic Compounds (2 credits, undergrad course)

Spectroscopic Methods in Organic Chemistry (3 credits, graduate course)


Representative Publications:

1. Lin, Q.; Li, P; Fang, M.; Zhang, D.; Xia, Y.*; “Deep-Profiling of Aminophospholipids Reveals Dysregulated Desaturation Pattern in Breast Cancer Cell Line”, Anal. Chem. 2022, 94, 820–828

2. Yang, X.; Zhang, L.; Xia, Y.*; “Photochemical Disulfide-ene Modification Enhances Protein Sequencing and Disulfide Mapping by Mass Spectrometry”, Anal. Chem., 2021, 93, 15231-15235

3. Xia, T.; Yuan, M.; Xu, Y.; Zhou, F.; Yu, K.*; Xia, Y.*; “Deep Structural Annotation of Glycerolipids by Charge-Tagging Paterno−Büchi Reaction and Supercritical Fluid Chromatography−Ion Mobility Mass Spectrometry”, Anal. Chem., 2021, 93, 8345–8353

4. Ma, X.; Zhang, W.; Li, Z.; Xia, Y.*, Z. Ouyang*; “Enabling High Structural Specificity to Lipidomics by Coupling Photochemical Derivatization with Tandem Mass Spectrometry”, Acc. Chem. Res., 2021, 54, 3873–3882

5. Adhikari, S.; Crehuet, R.; Anglada, J. M.*; Francisco, J. S.*; Xia, Y.*; “Two-step Reaction Mechanism Reveals New Antioxidant Capability of Cysteine Disulfides Against Hydroxyl Radical Attack”, Proc. Natl. Acad. Sci. USA, 2020, 117, 18216-18223

6. Zhang, W.; Zhang, D.; Chen, Q.; Wu, J.; Ouyang, Z.*; Xia, Y.*; “Online Photochemical Derivatization Enables Comprehensive Mass Spectrometric Analysis of Unsaturated Phospholipid Isomers, Nat. Commun., 2019, 10, 79

7. Zhao, X.; Zhang, W.; Zhang, D.; Liu, X.; Cao, W.; Chen, Q; Ouyang, Z.; Xia, Y.*; “A Lipidomic Workflow Capable of Resolving sn- and C=C Location Isomers of Phosphatidylcholines”, Chem. Sci., 2019, 10, 10740-10748

8. Ma, X.#; Chong, L.#; Tian, R.; Shi, R.; Hu, T. Y.; Ouyang, Z.*; Xia, Y.*; “Identification and Quantitation of Lipid C=C Location Isomers: A Shotgun Lipidomics Approach Enabled by Photochemical Reaction”, Proc. Natl. Acad. Sci. USA, 2016, 113, 2573-2578

9. Ma, X.; Xia, Y.*; “Pinpointing Double Bonds in Lipids by Paternò–Büchi Reactions and Mass Spectrometry”, Angew. Chem., Int. Ed, 2014, 53, 2592-2596.

10. Love, C. B.; Tan, L.; Francisco, J. S.*; Xia, Y.*; “Competition of Charge- vs. Radical-Directed Fragmentation of Gas-Phase Protonated Cysteine Sulfinyl Radicals”, J. Am. Chem. Soc., 2013, 135, 6226–6233.